Document 0098
 DOCN  M95B0098
 TI    Genetic variation among Pneumocystis carinii hominis isolates in
       recurrent pneumocystosis.
 DT    9511
 AU    Keely SP; Stringer JR; Baughman RP; Linke MJ; Walzer PD; Smulian AG;
       Cincinnati VA Medical Center, Ohio, USA.
 SO    J Infect Dis. 1995 Aug;172(2):595-8. Unique Identifier : AIDSLINE
       MED/95348572
 AB    Pneumocystis carinii hominis is a ubiquitous organism that causes
       pneumonia in immunocompromised persons. Paired P. carinii hominis
       isolates from human immunodeficiency virus-infected persons who had two
       episodes of pneumocystosis were examined for genetic heterogeneity.
       Genetic variation was detected by sequence comparison of a portion of
       the mitochondrial ribosomal RNA gene. In 5 of 10 patients experiencing
       two episodes of pneumocystosis, genetically distinct isolates were
       associated with each episode. These included 4 of 6 patients whose
       second episode of pneumocytosis occurred > 6 months after their initial
       bout. The genetic data support the hypothesis that some recurrent
       episodes of P. carinii hominis pneumonia are caused by reinfection
       rather than by reactivation of latent infection.
 DE    Alleles  AIDS-Related Opportunistic Infections/*GENETICS/MICROBIOLOGY
       Base Sequence  Bronchoalveolar Lavage Fluid/MICROBIOLOGY  Genes, Fungal
       Immunocompromised Host/GENETICS  Lung/MICROBIOLOGY
       Mitochondria/GENETICS  Molecular Sequence Data  Mutation  Pneumocystis
       carinii/*GENETICS/ISOLATION & PURIF  Pneumonia, Pneumocystis
       carinii/*GENETICS/MICROBIOLOGY  Recurrence  RNA/GENETICS  RNA,
       Fungal/GENETICS  RNA, Ribosomal/ANALYSIS  Support, U.S. Gov't,
       Non-P.H.S.  Support, U.S. Gov't, P.H.S.  *Variation (Genetics)  JOURNAL
       ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
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