Document 0099
 DOCN  M95B0099
 TI    Impact of Streptococcus pneumoniae bacteremia and human immunodeficiency
       virus type 1 on oral mucosal immunity.
 DT    9511
 AU    Opstad NL; Daley CL; Thurn JR; Rubins JB; Merrifield C; Hopewell PC;
       Janoff EN; Department of Medicine, VA Medical Center, University of;
       Minnesota School of Medicine, Minneapolis, MN 55417, USA.
 SO    J Infect Dis. 1995 Aug;172(2):566-70. Unique Identifier : AIDSLINE
       MED/95348564
 AB    To determine whether defects in mucosal immunity were associated with
       invasive disease caused by a mucosal pathogen, Streptococcus pneumoniae,
       levels of salivary immunoglobulins and nonspecific immune factors were
       compared in subjects with human immunodeficiency virus type 1 (HIV-1)
       infection and in HIV-1-seronegative subjects with and without
       pneumococcal bacteremia. The IgA2 subclass may be of particular
       importance because S. pneumoniae produces IgA1 protease, which cleaves
       IgA1 but not IgA2. Levels (37-56 micrograms/mL) and proportions
       (11%-17%) of IgA2 were similar among groups. Serotype-specific capsular
       salivary IgA was present in a minority of patients with acute
       bacteremia. Levels of lactoferrin were increased with bacteremia.
       Neither selective mucosal IgA2 deficiency nor impaired nonspecific upper
       respiratory mucosal responses were associated with invasive pneumococcal
       disease during HIV-1 infection; thus, other defects in mucosal cellular
       responses and systemic immunity may predispose HIV-1-infected patients
       to invasive pneumococcal disease.
 DE    Adolescence  Adult  AIDS-Related Opportunistic
       Infections/COMPLICATIONS/IMMUNOLOGY
       Bacteremia/COMPLICATIONS/*IMMUNOLOGY  Case-Control Studies  Female
       Human  HIV Seronegativity/IMMUNOLOGY  HIV
       Seropositivity/COMPLICATIONS/*IMMUNOLOGY  HIV-1/IMMUNOLOGY  Male  Middle
       Age  Mouth Mucosa/*IMMUNOLOGY  Pneumococcal
       Infections/COMPLICATIONS/*IMMUNOLOGY  Prospective Studies
       Saliva/IMMUNOLOGY  Salivary Glands/IMMUNOLOGY  Support, U.S. Gov't,
       Non-P.H.S.  Support, U.S. Gov't, P.H.S.  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).