Document 0100
 DOCN  M95B0100
 TI    Mapping of linear epitopes of the regulatory proteins of human T cell
       lymphotropic virus (HTLV) type II: identification of an
       HTLV-IIb-restricted epitope.
 DT    9511
 AU    Pardi D; Coligan JE; Lal RB; Retrovirus Diseases Branch, Centers for
       Disease Control and; Prevention, Atlanta, Georgia 30333, USA.
 SO    J Infect Dis. 1995 Aug;172(2):554-7. Unique Identifier : AIDSLINE
       MED/95348561
 AB    Epitope mapping analyses using synthetic peptides representing the RexII
       and TaxII proteins identified predominant seroreactivity to the carboxyl
       terminus of the HTLV-IIG12 TaxII protein (G12Tax 22-G12Tax24, amino
       acids [aa] 312-356). Moderate reactivity to only 1 RexII peptide
       (G12Rex9, aa 121-140) was found, while all other RexII and TaxII
       peptides exhibited minimal reactivity. Peptide G12Tax24 (aa 337-356)
       corresponded to the extended portion of the TaxII protein characteristic
       of HTLV-IIb viruses and appeared to represent an HTLV-IIb-restricted
       epitope. This study showed that this peptide can be used in immunoassays
       as a quick, simple serologic tool for assessing the minimal number of
       HTLV-IIb viruses present within specific populations, especially when
       genomic DNA is not available.
 DE    Amino Acid Sequence  Antibodies, Viral/*BLOOD  *Antigens, Viral
       Case-Control Studies  Gene Products, rex/*IMMUNOLOGY  Gene Products,
       tax/*IMMUNOLOGY  HTLV-II/*IMMUNOLOGY  HTLV-II
       Infections/IMMUNOLOGY/VIROLOGY  *Immunodominant Epitopes  Molecular
       Sequence Data  Peptide Fragments/IMMUNOLOGY  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).