Document 0102
 DOCN  M95B0102
 TI    Antiretroviral therapy suppresses the constitutive production of
       interleukin-1 associated with human immunodeficiency virus infection.
 DT    9511
 AU    Sadeghi HM; Weiss L; Kazatchkine MD; Haeffner-Cavaillon N; Department of
       Immunology, INSERM U430, Hopital Broussais, Paris,; France.
 SO    J Infect Dis. 1995 Aug;172(2):547-50. Unique Identifier : AIDSLINE
       MED/95348559
 AB    Interleukin (IL)-1 is constitutively produced by monocytes of human
       immunodeficiency virus (HIV)-seropositive persons. The changes in the
       production of IL-1 by monocytes of 24 HIV-infected patients were
       investigated during the course of 8 months of antiretroviral therapy. At
       month 8, the amounts of biologically active IL-1 and IL-1 alpha and
       -beta proteins produced by freshly obtained monocytes and by monocytes
       cultured for 24 h in the absence of lipopolysaccharide (LPS) decreased
       significantly compared with pretreatment values or decreased below the
       limits of detection in the assays. Antiretroviral therapy also resulted
       in enhanced secretion of IL-1 receptor antagonist (IL-1Ra) by
       LPS-stimulated patients' monocytes. The reduction in the constitutive
       production of IL-1 and the increased ability of stimulated cells to
       produce IL-1Ra associated with antiretroviral therapy may also be of
       importance in reducing a major pathway of amplification of viral
       replication in infected monocytes and lymphocytes.
 DE    Adult  Female  Human  HIV Seropositivity/*DRUG THERAPY/IMMUNOLOGY
       *HIV-1/DRUG EFFECTS/IMMUNOLOGY  Interleukin-1/*BIOSYNTHESIS
       Lipopolysaccharides/PHARMACOLOGY  Male  Middle Age  Monocytes/DRUG
       EFFECTS/IMMUNOLOGY/VIROLOGY  Support, Non-U.S. Gov't  Tumor Necrosis
       Factor/ANTAGONISTS & INHIB/BIOSYNTHESIS  Zidovudine/*THERAPEUTIC USE
       JOURNAL ARTICLE

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