Document 0104
 DOCN  M95B0104
 TI    Inhibition of the offspring anti-recombinant gp120 antibody response to
       a human immunodeficiency virus vaccine by maternal immunization in a
       murine model.
 DT    9511
 AU    Jelonek MT; Maskrey JL; Steimer KS; Potts BJ; Higgins KW; Keller MA;
       Department of Pediatrics, University of California, School of; Medicine,
       Harbor-UCLA Medical Center, Torrance 90509-2910, USA.
 SO    J Infect Dis. 1995 Aug;172(2):539-42. Unique Identifier : AIDSLINE
       MED/95348557
 AB    A murine model was developed for assessing the effects of passively
       transferred polyclonal maternal anti-gp120 antibodies on the subsequent
       immunization of the offspring with recombinant gp120SF2 in complete
       Freund's adjuvant (rgp120SF2-CFA). Adult female BALB/c mice were
       immunized with rgp120SF2-CFA 6 weeks before mating. The 3-week-old
       offspring were subsequently immunized with the same vaccine and followed
       for 9 weeks. Both the total IgG anti-rgp120SF2 and the anti-V3 IgG
       antibody response to vaccine were inhibited in the experimental animals.
       The total IgG anti-rgp120SF2 response was < 20% of the control response
       (P < .001) 9 weeks after immunization. Anti-V3 antibody was also
       decreased. As vaccine studies begin in infants, the effects of
       preexisting antibody on the infant response to human immunodeficiency
       virus vaccines must be considered.
 DE    Amino Acid Sequence  Animal  Antibodies, Viral/*BIOSYNTHESIS  AIDS
       Vaccines/*IMMUNOLOGY  HIV Envelope Protein gp120/*IMMUNOLOGY
       HIV-1/IMMUNOLOGY  Immunity, Maternally-Acquired/*IMMUNOLOGY
       Immunization, Passive  Mice  Mice, Inbred BALB C  Molecular Sequence
       Data  Peptide Fragments/*IMMUNOLOGY  Recombinant Proteins/IMMUNOLOGY
       Support, Non-U.S. Gov't  Support, U.S. Gov't, P.H.S.  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).