Document 0105
 DOCN  M95B0105
 TI    Squamous epithelial proliferative lesions associated with rhesus
       Epstein-Barr virus in simian immunodeficiency virus-infected rhesus
       monkeys.
 DT    9511
 AU    Baskin GB; Roberts ED; Kuebler D; Martin LN; Blauw B; Heeney J; Zurcher
       C; Department of Pathology, Tulane Regional Primate Research Center,;
       Tulane University, Covington, Louisiana 70433, USA.
 SO    J Infect Dis. 1995 Aug;172(2):535-9. Unique Identifier : AIDSLINE
       MED/95348556
 AB    Proliferative lesions were found on the squamous epithelium of the
       tongue, esophagus, or penis or haired skin of the lip, hand, or thorax
       of 8 simian immunodeficiency virus-infected rhesus monkeys that died of
       simian AIDS. The lesions were focal and consisted of hyperkeratosis,
       parakeratosis, and acanthosis in the skin, with additional ballooning
       degeneration in the tongue, esophagus, and penis. The epithelial
       surfaces were frequently colonized by Candida species or gram-positive
       cocci. Intranuclear inclusion bodies were seen in cells in the middle
       and superficial layers. Herpesvirus virions were found in
       inclusion-bearing cells by transmission electron microscopy. An
       Epstein-Barr-like virus was identified in inclusion-bearing cells by
       immunohistochemistry and in situ hybridization. No virus was detectable
       in basal layers of the epithelium. These lesions resemble oral hairy
       leukoplakia in AIDS patients and may thus provide a useful primate model
       to study permissive epithelial infection by Epstein-Barr-like viruses.
 DE    Animal  Epithelium/VIROLOGY  Herpesviridae Infections/*PATHOLOGY
       *Herpesvirus 4, Human  Macaca mulatta  Mucous Membrane/PATHOLOGY
       Opportunistic Infections/MICROBIOLOGY/PATHOLOGY  Simian Acquired
       Immunodeficiency Syndrome/*COMPLICATIONS/  PATHOLOGY  Skin/*PATHOLOGY
       Support, Non-U.S. Gov't  Support, U.S. Gov't, P.H.S.  Tumor Virus
       Infections/*PATHOLOGY  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).