Document 0106
 DOCN  M95B0106
 TI    Level of cytomegalovirus (CMV) DNA in cerebrospinal fluid of subjects
       with AIDS and CMV infection of the central nervous system.
 DT    9511
 AU    Arribas JR; Clifford DB; Fichtenbaum CJ; Commins DL; Powderly WG; Storch
       GA; Edward Mallinckrodt Department of Pediatrics, Washington; University
       School of Medicine, St. Louis, Missouri, USA.
 SO    J Infect Dis. 1995 Aug;172(2):527-31. Unique Identifier : AIDSLINE
       MED/95348554
 AB    The objective of this study was to correlate cytomegalovirus (CMV) DNA
       levels in the cerebrospinal fluid (CSF) of subjects with AIDS with
       clinical and pathologic findings attributable to CMV infection of the
       central nervous system (CNS). CMV polymerase chain reaction (PCR) was
       done on serial dilutions of CSF samples from 24 AIDS patients with
       autopsy-proven CNS disorders. CMV DNA was detected in CSF from 12 of 13
       subjects with evidence of CMV infection of the brain or spinal cord but
       in none of 11 subjects without autopsy evidence of CMV CNS infection.
       Subjects whose CSF contained > 10(3) CMV DNA molecules/8 microL of CSF
       had severe CMV CNS disease (e.g., ventriculoencephalitis). PCR appears
       to be more useful than clinical and neuroradiologic findings for
       documenting CMV infection of the CNS in patients with AIDS. Quantitation
       of CMV DNA in CSF shows promise for evaluation of the extent of
       involvement.
 DE    Acquired Immunodeficiency Syndrome/CEREBROSPINAL FLUID/
       *COMPLICATIONS/VIROLOGY  AIDS-Related Opportunistic
       Infections/CEREBROSPINAL FLUID/  COMPLICATIONS/*VIROLOGY  Case-Control
       Studies  Cytomegalovirus/*GENETICS/ISOLATION & PURIF  Cytomegalovirus
       Infections/CEREBROSPINAL FLUID/COMPLICATIONS/  *VIROLOGY  DNA,
       Viral/*CEREBROSPINAL FLUID  Human  Polymerase Chain Reaction/METHODS
       Support, U.S. Gov't, P.H.S.  Survival Rate  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).