Document 0112
 DOCN  M95B0112
 TI    Antibody class and subclass responses to pneumococcal polysaccharides
       following immunization of human immunodeficiency virus-infected
       patients.
 DT    9511
 AU    Carson PJ; Schut RL; Simpson ML; O'Brien J; Janoff EN; Department of
       Medicine, VA Medical Center, University of; Minnesota School of
       Medicine, Minneapolis, USA.
 SO    J Infect Dis. 1995 Aug;172(2):340-5. Unique Identifier : AIDSLINE
       MED/95348529
 AB    Antibodies of the IgM class and IgG2 and IgA2 subclasses are prominent
       in responses to pneumococcal polysaccharides (PPS) but may be decreased
       in human immunodeficiency virus (HIV)-infected patients, among whom
       invasive pneumococcal disease is common. After immunization of
       HIV-infected and -seronegative subjects with pneumococcal vaccine, the
       number of PPS-specific antibody-secreting cells (ASC) producing IgM was
       significantly lower among HIV-infected subjects, whereas PPS-specific
       IgG and IgA ASC were more comparable. The subclass distribution of
       PPS-specific IgG2-producing (approximately 80%) and IgA2-producing
       (approximately 50%) ASC and antibodies in serum were similar. However,
       before immunization, the proportions of PPS-specific IgG2 for both
       serotypes 8 and 14 in baseline sera from HIV-infected patients were
       significantly decreased compared with controls. Thus, the response to
       PPS among HIV-infected patients may be characterized by lower levels of
       specific IgG2 before immunization and prominent defects in IgM responses
       soon after stimulation.
 DE    Adult  Antibodies, Bacterial/CLASSIFICATION  Antibody-Producing
       Cells/IMMUNOLOGY  B-Lymphocytes/IMMUNOLOGY  Bacterial
       Vaccines/*IMMUNOLOGY  Case-Control Studies  Female  Human  HIV
       Infections/*IMMUNOLOGY  HIV Seronegativity/IMMUNOLOGY  IgA/*BIOSYNTHESIS
       IgG/*BIOSYNTHESIS  IgM/*BIOSYNTHESIS  Lymphocyte Transformation  Male
       Streptococcus pneumoniae/*IMMUNOLOGY  Support, U.S. Gov't, Non-P.H.S.
       Support, U.S. Gov't, P.H.S.  *Vaccination  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
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