Document 0113
 DOCN  M95B0113
 TI    Virus burden in long-term survivors of human immunodeficiency virus
       (HIV) infection is a determinant of anti-HIV CD8+ lymphocyte activity.
 DT    9511
 AU    Ferbas J; Kaplan AH; Hausner MA; Hultin LE; Matud JL; Liu Z; Panicali
       DL; Nerng-Ho H; Detels R; Giorgi JV; Department of Medicine, School of
       Medicine, University of; California at Los Angeles, USA.
 SO    J Infect Dis. 1995 Aug;172(2):329-39. Unique Identifier : AIDSLINE
       MED/95348528
 AB    Persons infected with human immunodeficiency virus (HIV) for > 8 years
       were studied to delineate virologic and immunologic attributes of
       long-term survival. Whereas those with 300-700 CD4+ cells/microL often
       had circulating cytotoxic T lymphocytes (CTL) against HIV antigens,
       those with > 1000 CD4+ cells/microL did not. The subjects with > 1000
       CD4+ cells/microL had low virus burden, low levels of Gag-specific CTL
       precursors, and minimal CD8+ cell activation. Overall, elevated levels
       of CD8+ cells, CD38 antigen expression on CD8+ cells, and anti-HIV
       functions were correlated with increased virus burden, provirus load,
       and HIV plasma RNA levels. A factor that suppressed HIV replication was
       spontaneously secreted from CD8+ cells of most subjects but not from
       those with high CD4+ cell counts. CD8+ cell activities, therefore, may
       reflect chronic viral stimulation of the immune system. Long-term
       survivors with high levels of CD4+ cells maintained control of viral
       replication but lacked the CD8+ cell activities.
 DE    Antibodies, Viral/IMMUNOLOGY  Antigens, CD/BIOSYNTHESIS  Antigens,
       Differentiation/BIOSYNTHESIS  Comparative Study  CD4 Lymphocyte Count
       CD4-Positive T-Lymphocytes/*VIROLOGY  CD8-Positive
       T-Lymphocytes/*IMMUNOLOGY  DNA, Viral/ANALYSIS  Follow-Up Studies  Human
       HIV/*ISOLATION & PURIF  HIV Seropositivity/IMMUNOLOGY/*VIROLOGY  HLA-DR
       Antigens/BIOSYNTHESIS  Lymphocyte Count  Lymphocyte Transformation  Male
       Nucleosidases/BIOSYNTHESIS  Receptors, Antigen, T-Cell/IMMUNOLOGY  RNA,
       Viral/ANALYSIS  Support, U.S. Gov't, P.H.S.  Survival Rate  Survivors
       T-Lymphocytes, Cytotoxic/IMMUNOLOGY  Viral Interference/IMMUNOLOGY
       Virus Cultivation  Virus Replication/IMMUNOLOGY  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).