Document 0115
 DOCN  M95B0115
 TI    Differential diagnosis of CNS lesions in AIDS patients by FDG-PET.
 DT    9511
 AU    Villringer K; Jager H; Dichgans M; Ziegler S; Poppinger J; Herz M;
       Kruschke C; Minoshima S; Pfister HW; Schwaiger M; Department of Nuclear
       Medicine, Curatorium for Immunodeficiency,; Munich, Germany.
 SO    J Comput Assist Tomogr. 1995 Jul-Aug;19(4):532-6. Unique Identifier :
       AIDSLINE MED/95348320
 AB    OBJECTIVE: The aim of this study was to evaluate the potential of
       FDG-PET in the differential diagnosis of CNS lesions in patients with
       AIDS, particularly to differentiate between toxoplasmosis and lymphoma.
       MATERIALS AND METHODS: We examined 11 AIDS patients, 6 with
       toxoplasmosis, 1 with a tuberculoma, and 4 with a primary CNS lymphoma.
       The FDG uptake within the lesion was compared with the uptake in a
       contralateral brain area [standardized uptake value (SUV)]. RESULTS: In
       all subjects with cerebral infections (toxoplasmosis, tuberculoma), the
       SUV ratio was significantly (p < 0.05) lower than the SUV ratio in
       patients with lymphoma (range of 0.3-0.7 vs. 1.7-3.1) with no overlap of
       the uptake values. CONCLUSION: In conclusion, FDG-PET may help to
       characterize these lesions metabolically and play an important role in
       the clinical management of AIDS patients with CNS involvement.
 DE    Adult  AIDS-Related Opportunistic Infections/*RADIONUCLIDE IMAGING
       Brain/RADIONUCLIDE IMAGING  Central Nervous System
       Neoplasms/*RADIONUCLIDE IMAGING  Deoxyglucose/*ANALOGS &
       DERIVATIVES/DIAGNOSTIC USE  Diagnosis, Differential  Evaluation Studies
       Female  Fluorine Radioisotopes/*DIAGNOSTIC USE  Follow-Up Studies  Human
       Lymphoma, AIDS-Related/*RADIONUCLIDE IMAGING  Male  Support, Non-U.S.
       Gov't  Time Factors  Tomography, Emission-Computed  Toxoplasmosis,
       Cerebral/*RADIONUCLIDE IMAGING  Tuberculoma, Intracranial/*RADIONUCLIDE
       IMAGING  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).