Document 0121
 DOCN  M95B0121
 TI    Modulation of immune function and cytokine production by various levels
       of vitamin E supplementation during murine AIDS.
 DT    9511
 AU    Wang Y; Huang DS; Wood S; Watson RR; Department of Family and Community
       Medicine, University of; Arizona, Tucson 85724, USA.
 SO    Immunopharmacology. 1995 Apr;29(3):225-33. Unique Identifier : AIDSLINE
       MED/95347954
 AB    Female C57BL/6 mice were infected with LP-BM5 retrovirus, causing murine
       AIDS which is functionally similar to human AIDS. Dietary
       supplementation, with a 15-, 150- and 450-fold increase of vitamin E in
       a liquid diet, significantly restored levels of interleukin-2 (IL) and
       interferon-gamma produced by splenocytes, which were suppressed by
       retrovirus infection. Retrovirus infection elevated levels of IL-6 and
       IL-10 produced by splenocytes, which were significantly normalized by
       all levels of vitamin E supplementation, respectively. Increased levels
       of IL-6 and tumor necrosis factor-alpha, produced by splenocytes during
       progression to murine AIDS, were also significantly normalized by all
       levels of vitamin E supplementation. Vitamin E supplementation restored
       retrovirus-suppressed splenocyte proliferation and natural killer cell
       cytotoxicity. Vitamin E supplementation also alleviated the AIDS
       symptoms: splenomegaly and hypergammaglobulinemia. These data indicate
       that dietary vitamin E supplementation at extremely high levels was not
       immunotoxic, and can modulate cytokine release and normalize immune
       dysfunctions during progression to murine AIDS. It should favorably
       affect host resistance and thereby retard the development of AIDS.
 DE    Animal  Cytokines/*BIOSYNTHESIS/IMMUNOLOGY  Cytotoxicity,
       Immunologic/DRUG EFFECTS  Female  *Immunity, Cellular  Interferon Type
       II/BIOSYNTHESIS  Interleukins/BIOSYNTHESIS  Killer Cells,
       Natural/IMMUNOLOGY  Leukemia Viruses, Murine/DRUG EFFECTS  Liver/DRUG
       EFFECTS/METABOLISM  Lymphocyte Transformation/DRUG EFFECTS  Mice  Mice,
       Inbred C57BL  Murine Acquired Immunodeficiency Syndrome/*DRUG THERAPY/
       IMMUNOLOGY  Retroviridae Infections/DRUG THERAPY/VIROLOGY
       Spleen/CYTOLOGY/IMMUNOLOGY  Tumor Necrosis Factor/BIOSYNTHESIS  Vitamin
       E/ADMINISTRATION & DOSAGE/ANALYSIS/*THERAPEUTIC USE  JOURNAL ARTICLE

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