Document 0123
 DOCN  M95B0123
 TI    T-cell cytokine responses in human infection with Mycobacterium
       tuberculosis.
 DT    9511
 AU    Zhang M; Lin Y; Iyer DV; Gong J; Abrams JS; Barnes PF; Department of
       Medicine, University of Southern California School; of Medicine, Los
       Angeles 90033, USA.
 SO    Infect Immun. 1995 Aug;63(8):3231-4. Unique Identifier : AIDSLINE
       MED/95347850
 AB    Compared with healthy tuberculin reactors, Mycobacterium
       tuberculosis-stimulated peripheral blood mononuclear cells from
       tuberculosis patients had diminished production and mRNA expression of
       the Th1 cytokines gamma interferon and interleukin 2 (IL-2), with no
       change in production and mRNA expression for the Th2 cytokines IL-4,
       IL-10, and IL-13. These results were confirmed by evaluation of T cells
       and CD4+ cells. At the level of systemic T cells, development of
       tuberculosis is associated with diminished Th1 but not enhanced Th2
       responses.
 DE    Adult  Base Sequence  Cytokines/*BIOSYNTHESIS/GENETICS  DNA
       Primers/CHEMISTRY  Female  Gene Expression  Human  Killer Cells,
       Natural/IMMUNOLOGY  Male  Middle Age  Molecular Sequence Data
       Mycobacterium tuberculosis/*IMMUNOLOGY  RNA, Messenger/GENETICS
       Support, Non-U.S. Gov't  Support, U.S. Gov't, P.H.S.
       T-Lymphocytes/*IMMUNOLOGY  Th1 Cells/IMMUNOLOGY  Th2 Cells/IMMUNOLOGY
       Time Factors  Tuberculosis/*IMMUNOLOGY  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).