Document 0127
 DOCN  M95B0127
 TI    Expansion of gamma delta+ T cells in BALB/c mice infected with
       Leishmania major is dependent upon Th2-type CD4+ T cells.
 DT    9511
 AU    Rosat JP; Conceicao-Silva F; Waanders GA; Beermann F; Wilson A; Owen MJ;
       Hayday AC; Huang S; Aguet M; MacDonald HR; et al; World Health
       Organization Immunology Research and Training; Center, University of
       Lausanne, Epalinges, Switzerland.
 SO    Infect Immun. 1995 Aug;63(8):3000-4. Unique Identifier : AIDSLINE
       MED/95347814
 AB    T cells belong to either the alpha beta+ or gamma delta+ lineage as
       defined by their antigen receptor. Although both T-cell subsets have
       been shown to be involved in the immune response to the parasite
       Leishmania major, very little is known about possible interactions
       between these two populations. In this study, using a mouse model of
       infection with L. major, we showed that expansion of a subset of gamma
       delta+ T cells in vivo is dependent upon the presence of alpha beta+
       CD4+ T cells. Moreover, this effect appears to be mediated via the
       secretion of lymphokines by CD4+ cells with a T-helper 2 (Th2)
       functional phenotype. Results showing that activation of Th2-type cells
       in mice treated with anti-immunoglobulin D antibodies or infected with
       Nippostrongylus brasiliensis also results in gamma delta+ T-cell
       expansion suggest that this effect of the Th2-type CD4+ cells is a
       general phenomenon not restricted to infection with L. major.
 DE    Animal  CD8-Positive T-Lymphocytes/IMMUNOLOGY  Leishmania
       major/*IMMUNOLOGY  Leishmaniasis, Cutaneous/*IMMUNOLOGY  Lymphocyte
       Transformation  Mice  Mice, Inbred BALB C  Mice, Inbred CBA  Mice,
       Inbred C57BL  Mice, Nude  Nippostrongylus/IMMUNOLOGY  Receptors,
       Antigen, T-Cell, gamma-delta/*IMMUNOLOGY  Strongylida
       Infections/IMMUNOLOGY  Support, Non-U.S. Gov't  T-Lymphocyte
       Subsets/*IMMUNOLOGY  Th1 Cells/IMMUNOLOGY  Th2 Cells/*IMMUNOLOGY
       JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).