Document 0130
 DOCN  M95B0130
 TI    Outcome of infection with different strains of Trypanosoma cruzi in mice
       lacking CD4 and/or CD8.
 DT    9511
 AU    Rottenberg ME; Riarte A; Sporrong L; Altcheh J; Petray P; Ruiz AM;
       Wigzell H; Orn A; Immunology Laboratory, Karolinska Institute,
       Stockholm, Sweden.
 SO    Immunol Lett. 1995 Feb;45(1-2):53-60. Unique Identifier : AIDSLINE
       MED/95347764
 AB    Mice lacking CD4 and/or CD8 gene expression, generated by embryonic
       stem-cell technology, were used to study the role of CD4+ and CD8+ cells
       in the resistance to the acute infection with virulent (Tulahuen and RA)
       or mild (CA-I) strains of Trypanosoma cruzi. The presence of both CD4+
       and CD8+ cells contributed to the survival of mice infected with T.
       cruzi, and each T-cell subtype was able to sustain protective functions
       in the absence of the other one. However, in certain host-parasite
       combinations, CD8+ cell-independent mechanisms were able to control the
       parasite load. Moreover, CD8- mice chronically infected with a low
       virulent strain of T. cruzi were protected from an otherwise lethal
       challenge with the parasite. A different organ distribution of parasite
       nests was observed when mutant (but not wild type) animals infected with
       different parasite strains were compared. CD4- mice produced high levels
       of IgG antibodies against peptide antigens or a whole homogenate from
       the parasite after infection with CA-I strain. A dramatic enhancement of
       IgG1- and IgG2a-specific antibodies was observed.
 DE    Amino Acid Sequence  Animal  Antigens, CD4/GENETICS/*PHYSIOLOGY
       Antigens, CD8/GENETICS/*PHYSIOLOGY  Antigens, Protozoan/*IMMUNOLOGY
       Chagas Disease/COMPLICATIONS/*IMMUNOLOGY  CD4-Positive
       T-Lymphocytes/*IMMUNOLOGY  CD8-Positive T-Lymphocytes/*IMMUNOLOGY  H-2
       Antigens/IMMUNOLOGY  IgG/IMMUNOLOGY  Immunologic Deficiency
       Syndromes/COMPLICATIONS/*IMMUNOLOGY  Mice  Mice, Knockout  Molecular
       Sequence Data  Support, Non-U.S. Gov't  Trypanosoma
       cruzi/*IMMUNOLOGY/PATHOGENICITY  Virulence  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).