Document 0134
 DOCN  M95B0134
 TI    Interaction of avian sarcoma/leukemia viruses with heterologous hosts:
       inference for host-range and some pathogenic properties of human
       immunodeficiency viruses.
 DT    9511
 AU    Popovic M; Grofova M; Microbiology and Tumorbiology Center, Karolinska
       Institutet,; Stockholm, Sweden.
 SO    Folia Biol (Praha). 1995;41(1):1-14. Unique Identifier : AIDSLINE
       MED/95347505
 AB    Although there are substantial differences between retroviruses
       originating from avian and primate species, a comparison of these two
       different biological systems reveals that interaction of these
       retroviruses with heterologous hosts involves similar biological
       principles. Retroviral isolates with high replicative capacity in
       natural targets (e.g. CD4+ lymphocytes and macrophages for human
       immunodeficiency viruses (HIVs) can infect other cell types [e.g. CD-
       astrocytes, follicular dendritic cells (FDC) in vivo and/or CD4+
       neoplastic T cells in vitro] as well. These viral isolates may have a
       potential of infecting heterologous cells in vitro and can enlarge their
       host-range by establishing infection in other species, distantly
       related. Strains of avian sarcoma/leukemia viruses (ASLV) originating
       from their natural hosts, chickens, and infectious for other avian
       species, ducks, can frequently infect mammals (rodents). Similarly,
       HIV-1 strains infectious for chimpanzees possess capacity of
       establishing chronic infection in pig-tailed macaques. The broad
       host-range of retroviral isolates in both viral systems is accompanied
       by presence of additional structures in viral envelope. These novel or
       additional envelope structures may recognize alternate viral
       receptor(s). Moreover, the enlarged host range of primary HIV-1 isolates
       is evaluated by infection of neoplastic CD4+ permanent cell line, MT2,
       and serves as a predictive marker of progression of the viral infection
       toward AIDS.
 DE    Animal  Chickens/*VIROLOGY  CD4-Positive T-Lymphocytes/VIROLOGY  Human
       HIV/*PATHOGENICITY  Mice  Retroviruses,
       ALV-Related/IMMUNOLOGY/*PHYSIOLOGY  Support, Non-U.S. Gov't  JOURNAL
       ARTICLE  REVIEW  REVIEW, TUTORIAL

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).