Document 0138
 DOCN  M95B0138
 TI    Are CD8 T cells involved in control of African trypanosomiasis in a
       natural host environment?
 DT    9511
 AU    Sileghem M; Naessens J; Trypanosomiasis Programme, International
       Livestock Research; Institute, Nairobi, Kenya.
 SO    Eur J Immunol. 1995 Jul;25(7):1965-71. Unique Identifier : AIDSLINE
       MED/95347396
 AB    Murine models have suggested that CD8 T cells might play a major
       parasite-promoting role in African trypanosomiasis. To assess the role
       of these cells in a natural host environment, we have depleted CD8 cells
       from Boran cattle in vivo and subsequently infected these animals with
       Trypanosoma congolense by tsetse fly challenge. Following administration
       of a mouse monoclonal anti-bovine CD8 antibody, we have been able to
       achieve a depletion of more than 99.9% in peripheral blood, spleen,
       prescapular lymph nodes, prefemoral lymph nodes, mesenteric lymph nodes
       and Peyer's patches. Depletion could be maintained over a 4-5-week
       infection period. Despite the almost total absence of CD8 cells, no
       effect whatsoever was observed on parasitemia. In addition, anemia,
       which is the main factor determining the mean survival time in cattle
       was not affected by the CD8 depletion.
 DE    Animal  Antibodies, Monoclonal/THERAPEUTIC USE  Cattle  Cattle
       Diseases/*IMMUNOLOGY/PREVENTION & CONTROL/PARASITOLOGY  CD8-Positive
       T-Lymphocytes/*IMMUNOLOGY  Human  Lymph Nodes/CYTOLOGY  Lymphocyte
       Depletion  Time Factors  Trypanosoma congolense/IMMUNOLOGY
       Trypanosomiasis, African/*IMMUNOLOGY/PREVENTION & CONTROL  JOURNAL
       ARTICLE

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