Document 0146
 DOCN  M95B0146
 TI    Common variable immunodeficiency (CVID) and MxA-protein expression in
       blood leucocytes.
 DT    9511
 AU    Rump JA; Jakschiess D; Walker U; Schlesier M; von Wussow P; Peter HH;
       Abteilung Rheumatologie, Med. Univ. Klinik, Freiburg, Germany.
 SO    Clin Exp Immunol. 1995 Jul;101(1):89-93. Unique Identifier : AIDSLINE
       MED/95347088
 AB    The underlying immunopathogenic mechanism of CVID has been suspected to
       involve a chronic viral infection or an autoimmune condition. However,
       formal proof of viral infection is lacking. Measurement of MxA-protein
       in leucocyte lysates is a sensitive test for evaluating the activation
       of the host's interferon system. Both viral infections and autoimmune
       diseases such as systemic lupus erythematosus (SLE) strongly induce
       MxA-protein in peripheral leucocytes. We therefore examined 15 patients
       with longlasting hypogammaglobulinaemia for MxA-protein induction in
       vivo: 13 patients suffered from CVID, one from hyper-IgM syndrome, and
       one patient had chronic B lymphocytic leukaemia associated with
       immunoglobulin deficiency and chronic papilloma virus infection
       (condylomata accuminata). Only the latter patient exhibited a strong
       MxA-protein expression; two CVID patients were borderline positive, and
       the remaining 12 patients including the hyper-IgM syndrome were
       MxA-protein-negative. There was no relationship between MxA expression
       and low CD4/CD8 ratios or increased CD8/CD57+ T cell counts, although
       both conditions are often observed in CVID as well as in chronic viral
       infections. When exposed in vitro to interferon-alpha (IFN-alpha),
       peripheral blood leucocytes of four MxA-negative patients were capable
       of producing normal amounts of MxA-protein. Taken together, these
       results argue against a viral or autoimmune pathogenesis of CVID.
 DE    Adult  Aged  Antigens, CD/BIOSYNTHESIS  Antigens, CD8/BIOSYNTHESIS
       Antigens, Differentiation, T-Lymphocyte/BIOSYNTHESIS  Common Variable
       Immunodeficiency/*METABOLISM  CD4-CD8 Ratio  Female  Human
       Leukocytes/*CHEMISTRY  Lymphocytes/METABOLISM  Male  Middle Age
       Proteins/*BIOSYNTHESIS  Virus Inhibitors/PHYSIOLOGY  JOURNAL ARTICLE

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