Document 0149
 DOCN  M95B0149
 TI    Decreased cervicovaginal production of both IgA1 and IgA2 subclasses in
       women with AIDS.
 DT    9511
 AU    Belec L; Meillet D; Gaillard O; Prazuck T; Michel E; Ngondi Ekome J;
       Pillot J; Unite d'Immunologie Microbienne, Institut Pasteur, Paris,;
       France.
 SO    Clin Exp Immunol. 1995 Jul;101(1):100-6. Unique Identifier : AIDSLINE
       MED/95347060
 AB    Paired sera and cervicovaginal secretions from 35 HIV-1-infected women
       representing different CDC stages of HIV infection were evaluated for
       total IgA, IgA1 and IgA2, for IgA, IgA1 and IgA2 to gp160, and for
       albumin. Age-matched healthy women (n = 45) served as controls. The
       secretion rates of total IgA, IgA1 and IgA2 were evaluated by
       calculating their relative coefficients of excretion by reference to
       albumin. In HIV-infected women, total IgA1 and IgA2 in sera and in
       cervicovaginal secretions increased proportionately as early as stages
       II + III and more markedly at stage IV. By contrast, the secretion rates
       of total IgA IgA1 and IgA2 were markedly reduced in AIDS women, the IgA2
       secretion rate decreasing significantly as early as stages II + III.
       This apparent discrepancy was probably the result of increased
       transudation of serum-borne immunoglobulins into the vaginal cavity,
       since albumin levels in cervicovaginal secretions increased
       significantly according to the stages of disease. HIV-reactive IgA
       antibodies in serum, as in cervicovaginal secretions, were principally
       found within the IgA1 subclass. In women at stage IV, a high local
       production of IgA1 to gp160 occurred in spite of the impairment of
       cervicovaginal IgA synthesis, probably because of marked genital HIV
       replication at advanced stages.
 DE    Acquired Immunodeficiency Syndrome/*METABOLISM  Adolescence  Adult
       Antibody Specificity  Cervix Uteri/*METABOLISM/SECRETION  Female  Gene
       Products, env/IMMUNOLOGY  Human  IgA/*BIOSYNTHESIS/*BLOOD/IMMUNOLOGY
       Protein Precursors/IMMUNOLOGY  Serum Albumin/ANALYSIS  Support, Non-U.S.
       Gov't  Vagina/*METABOLISM/SECRETION  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).