Document 0152
 DOCN  M95B0152
 TI    Virus receptors: implications for pathogenesis and the design of
       antiviral agents.
 DT    9511
 AU    Norkin LC; Department of Microbiology, University of Massachusetts,
       Amherst; 01003, USA.
 SO    Clin Microbiol Rev. 1995 Apr;8(2):293-315. Unique Identifier : AIDSLINE
       MED/95346873
 AB    A virus initiates infection by attaching to its specific receptor on the
       surface of a susceptible host cell. This prepares the way for the virus
       to enter the cell. Consequently, the expression of the receptor on
       specific cells and tissues of the host is a major determinant of the
       route of entry of the virus into the host and of the patterns of virus
       spread and pathogenesis in the host. This review emphasizes the
       virus-receptor interactions of human immunodeficiency virus, the
       rhinoviruses, the herpesviruses, and the coronaviruses. These
       interactions are often found to be complex and dynamic, involving
       multiple sites or factors on both the virus and the host cell. Also, the
       receptor may play an important role in virus entry per se in addition to
       its role in virus binding. In the cases of human immunodeficiency virus
       and the rhinoviruses, ingenious approaches to therapeutic strategies
       based on inhibiting virus attachment and entry are under development and
       in clinical trials.
 DE    Antigens, CD4/CHEMISTRY/PHYSIOLOGY  Antiviral
       Agents/PHARMACOLOGY/*THERAPEUTIC USE  Coronavirus/DRUG
       EFFECTS/PHYSIOLOGY/PATHOGENICITY  Drug Design  Herpesviridae/DRUG
       EFFECTS/PHYSIOLOGY/PATHOGENICITY  Human  HIV/DRUG
       EFFECTS/PHYSIOLOGY/PATHOGENICITY  Intercellular Adhesion
       Molecule-1/CHEMISTRY/PHYSIOLOGY  Models, Molecular  Picornaviridae/DRUG
       EFFECTS/PHYSIOLOGY/PATHOGENICITY  Receptors, Virus/DRUG
       EFFECTS/*PHYSIOLOGY  Retroviridae/DRUG EFFECTS/PHYSIOLOGY/PATHOGENICITY
       Support, U.S. Gov't, Non-P.H.S.  Support, U.S. Gov't, P.H.S.  JOURNAL
       ARTICLE  REVIEW  REVIEW, ACADEMIC

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).