Document 0154
 DOCN  M95B0154
 TI    Tuberculosis in the AIDS era.
 DT    9511
 AU    Sepkowitz KA; Raffalli J; Riley L; Kiehn TE; Armstrong D; Infectious
       Disease Service, Memorial Sloan-Kettering Cancer; Center, New York, NY
       10021, USA.
 SO    Clin Microbiol Rev. 1995 Apr;8(2):180-99. Unique Identifier : AIDSLINE
       MED/95346868
 AB    A resurgence of tuberculosis has occurred in recent years in the United
       States and abroad. Deteriorating public health services, increasing
       numbers of immigrants from countries of endemicity, and coinfection with
       the human immunodeficiency virus (HIV) have contributed to the rise in
       the number of cases diagnosed in the United States. Outbreaks of
       resistant tuberculosis, which responds poorly to therapy, have occurred
       in hospitals and other settings, affecting patients and health care
       workers. This review covers the pathogenesis, epidemiology, clinical
       presentation, laboratory diagnosis, and treatment of Mycobacterium
       tuberculosis infection and disease. In addition, public health and
       hospital infection control strategies are detailed. Newer approaches to
       epidemiologic investigation, including use of restriction fragment
       length polymorphism analysis, are discussed. Detailed consideration of
       the interaction between HIV infection and tuberculosis is given. We also
       review the latest techniques in laboratory evaluation, including the
       radiometric culture system, DNA probes, and PCR. Current recommendations
       for therapy of tuberculosis, including multidrug-resistant tuberculosis,
       are given. Finally, the special problem of prophylaxis of persons
       exposed to multidrug-resistant tuberculosis is considered.
 DE    AIDS-Related Opportunistic Infections/DIAGNOSIS/*EPIDEMIOLOGY/
       MICROBIOLOGY  BCG Vaccine  Cross Infection  Human  Infection Control
       Polymerase Chain Reaction
       Tuberculosis/COMPLICATIONS/DIAGNOSIS/*EPIDEMIOLOGY/THERAPY
       Tuberculosis, Multidrug-Resistant/COMPLICATIONS/EPIDEMIOLOGY/  THERAPY
       JOURNAL ARTICLE  REVIEW  REVIEW, ACADEMIC

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).