Document 0162
 DOCN  M95B0162
 TI    Specific immunity to Listeria monocytogenes in the absence of IFN gamma.
 DT    9511
 AU    Harty JT; Bevan MJ; Department of Microbiology, University of Iowa, Iowa
       City 52242,; USA.
 SO    Immunity. 1995 Jul;3(1):109-17. Unique Identifier : AIDSLINE
       MED/95346501
 AB    Cytokine and cytokine receptor gene knockout mice provide powerful
       experimental systems to characterize the functions of these molecules in
       resistance to infectious disease. Such mice may also provide unique
       models of immune deficiency to learn whether manipulation of the immune
       response can overcome the specific dysfunction. We demonstrate that
       resistance of IFN gamma gene knockout (GKO-/-) mice to the intracellular
       bacterium Listeria monocytogenes is severely impaired compared with
       wild-type mice. However, immunization of GKO-/- mice with an attenuated
       L. monocytogenes strain generates antigen-specific CD8 T cell responses
       that can transfer immunity to naive hosts. Furthermore, vaccinated
       GKO-/- mice themselves exhibit 20,000-fold increased resistance to
       challenge with virulent L. monocytogenes and this resistance appears to
       be CD8 T cell mediated. These studies demonstrate that
       vaccination-induced immunity can overcome the absence of a cytokine that
       is critical for resistance to acute infection.
 DE    Animal  CD8-Positive T-Lymphocytes/IMMUNOLOGY  Immunity  Immunization,
       Passive  Interferon Type II/DEFICIENCY/*IMMUNOLOGY  Listeria
       monocytogenes/*IMMUNOLOGY  Mice  Mice, Inbred BALB C  Mice, Knockout
       Support, Non-U.S. Gov't  Support, U.S. Gov't, P.H.S.  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).