Document 0163
 DOCN  M95B0163
 TI    Epidermal Langerhans' cells and their function in the skin immune
       system.
 DT    9511
 AU    Hogan AD; Burks AW; Department of Pediatrics, Arkansas Children's
       Hospital,; University of Arkansas for Medical Science, Little Rock, USA.
 SO    Ann Allergy Asthma Immunol. 1995 Jul;75(1):5-10; quiz 10-2. Unique
       Identifier : AIDSLINE MED/95346491
 AB    OBJECTIVE: This article reviews the role of the epidermal Langerhans'
       cell in contact dermatitis and atopic dermatitis. Included in this
       review are sections on the historical, morphologic, immunohistochemical,
       and electron microscopic aspects of the Langerhans' cell. Differences
       between freshly isolated and cultured Langerhans' cells are reviewed in
       terms of cell surface markers and functional differences. The different
       IgE binding structures on the surface of Langerhans' cells are reviewed
       with discussion of their possible roles. The effects of different
       cytokines in the microenvironment are also commented upon. Other
       diseases where the Langerhans' cell is important such as histiocytosis
       X, HIV-1 infection, and skin graft rejection are briefly reviewed. DATA
       SOURCES: English literature search (1974-1994), indexing terms:
       Langerhans' cells, atopic dermatitis, IgE. STUDY SELECTION: The purpose
       of this paper is to review the most recent knowledge of Langerhans' cell
       function and relate this to the allergist/immunologist.
       RESULTS/CONCLUSIONS: Epidermal Langerhans' cells play a central role in
       the immune response in exhibiting multiple cell-surface receptors and
       secreting a variety of cytokines that are important in the pathogenesis
       of contact dermatitis, atopic dermatitis, histiocytosis X, HIV-1
       infection, and skin graft rejection.
 DE    Epidermis/IMMUNOLOGY/PATHOLOGY  Human  Langerhans
       Cells/*IMMUNOLOGY/METABOLISM/PATHOLOGY  Questionnaires
       Skin/*IMMUNOLOGY/ULTRASTRUCTURE  Support, Non-U.S. Gov't  JOURNAL
       ARTICLE  REVIEW  REVIEW, TUTORIAL

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).