Document 0172
 DOCN  M95B0172
 TI    Strain-dependent migration of CD4 and CD8 lymphocyte subsets to lymph
       nodes in NOD (nonobese diabetic) and control mice.
 DT    9511
 AU    Faveeuw C; Gagnerault MC; Lepault F; CNRS URA 1461, Hopital Necker,
       Paris, France.
 SO    Dev Immunol. 1994;3(4):273-82. Unique Identifier : AIDSLINE MED/95345683
 AB    Subpopulations of lymphoid cells were compared with respect to their
       ability to migrate into peripheral lymphoid organs of nonobese diabetic
       (NOD) mice and various strains of control mice. In short-term, in vivo
       homing studies, no major differences in the pattern of homing of B and T
       cells were observed among all mouse strains studied. On the other hand,
       CD4 cells localized consistently more efficiently than CD8 cells in both
       PP and LN of adult NOD and BALB/c mice, whereas both populations
       migrated roughly equivalently in LN of adult DBA/2, CBA, and C57BL/6
       mice. No age-dependent differences in the homing of CD4 and CD8 cells
       were observed in BALB/c mice. On the contrary, in 2-week-old NOD mice,
       CD4 and CD8 cells migrated equally well. The preferential entry of CD4
       cells in adult NOD and BALB/c did not result from increased blood
       transit time of CD8 cells. On the other hand, the preferential migration
       of CD8 cells was observed in the liver, whereas the two T-cell subsets
       migrated equally well in the lungs. The differences in the homing
       characteristics of CD4 and CD8 cells among NOD, BALB/c, and C57BL/6 mice
       were not related to modifications in the level of expression of adhesion
       molecules such as MEL-14, LFA-1, and Pgp-1.
 DE    Age Factors  Animal  Cell Adhesion Molecules/BIOSYNTHESIS  Cell
       Movement/GENETICS  Cells, Cultured  CD4-Positive
       T-Lymphocytes/*CYTOLOGY/METABOLISM  CD8-Positive
       T-Lymphocytes/*CYTOLOGY/METABOLISM  Female  Liver/CYTOLOGY  Lymph
       Nodes/*CYTOLOGY  Mice  Mice, Inbred BALB C  Mice, Inbred C57BL  Mice,
       Inbred NOD/GENETICS  Support, Non-U.S. Gov't  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).