Document 0190
 DOCN  M95B0190
 TI    Persistent coccidioidal seropositivity without clinical evidence of
       active coccidioidomycosis in patients infected with human
       immunodeficiency virus.
 DT    9511
 AU    Arguinchona HL; Ampel NM; Dols CL; Galgiani JN; Mohler MJ; Fish DG;
       Medical Service, Veterans Affairs Medical Center, Tucson, Arizona;
       85723, USA.
 SO    Clin Infect Dis. 1995 May;20(5):1281-5. Unique Identifier : AIDSLINE
       MED/95345298
 AB    We retrospectively identified 13 patients infected with human
       immunodeficiency virus (HIV) who had persistently positive coccidioidal
       serological tests without evidence of active coccidioidomycosis--to our
       knowledge, a heretofore undescribed phenomenon. The median duration of
       follow-up was 19 months. Five patients developed active
       coccidioidomycosis during this follow-up period; the median interval
       from the initial positive serological test to the development of active
       disease was 23 months. There were no significant differences between
       patients who developed active coccidioidomycosis and those who did not
       with regard to CD4 lymphocyte count or previous antifungal therapy.
       Moreover, when all 13 patients were compared with 21 patients who had
       HIV infection and active coccidioidomycosis, no differences were found
       with regard to age, race, risk factor for HIV infection, or initial CD4
       lymphocyte count. In summary, persistently positive coccidioidal
       serological tests in HIV-infected patients appear to represent true
       coccidioidal infection and are associated with a significant risk of the
       development of active coccidioidomycosis.
 DE    Adult  Antibodies, Fungal/*BLOOD  Coccidioides/*IMMUNOLOGY
       Coccidioidomycosis/*ETIOLOGY  Human  HIV Infections/*IMMUNOLOGY  Middle
       Age  Retrospective Studies  Serodiagnosis  Support, U.S. Gov't,
       Non-P.H.S.  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
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