Document 0191
 DOCN  M95B0191
 TI    An epidemiologic analysis of Mycobacterium avium complex disease in
       homosexual men infected with human immunodeficiency virus type 1.
 DT    9511
 AU    Hoover DR; Graham NM; Bacellar H; Murphy R; Visscher B; Anderson R;
       McArthur J; Johns Hopkins School of Hygiene and Public Health,
       Department of; Epidemiology, Baltimore, Maryland 21205, USA.
 SO    Clin Infect Dis. 1995 May;20(5):1250-8. Unique Identifier : AIDSLINE
       MED/95345293
 AB    Cofactors associated with the Mycobacterium avium complex (MAC) disease
       and its prognosis in incident cases of AIDS in homosexuals were studied.
       We compared 51 men in whom MAC disease developed as the initial
       AIDS-defining illness (termed AIDS illness hereafter); 157 men who had
       MAC disease subsequent to another AIDS illness; and 884 men who had only
       non-MAC AIDS illnesses. MAC disease was the initially diagnosed AIDS
       illness more often in Baltimore (6.9%) and Los Angeles (5.6%) than in
       Chicago (2.6%) and Pittsburgh (0) (P < .01). MAC disease also was a more
       common subsequent AIDS illness in Baltimore (14.3%) and Los Angeles
       (22.4%) than in Chicago (8.5%) and Pittsburgh (6.5%) (P < .0001).
       Prophylaxis for Pneumocystis carinii infection increased the occurrence
       of MAC disease as the initial AIDS illness (from 2.3% to 12.5%; P <
       .0001). A low white blood cell (WBC) count was slightly more predictive
       of MAC disease than was a low CD4+ cell count. At 0-6, 7-12, and 13-18
       months before diagnosis, the WBC cell counts of 75.0%, 61.1%, and 50.0%,
       respectively, of those with MAC disease as the initial AIDS illness were
       < or = 3,400/microL. Men in whom cytomegalovirus disease developed were
       at higher risk for subsequent MAC disease (relative hazard = 2.65; P <
       .0001). MAC disease also increased the risk for subsequent
       cytomegalovirus disease (relative hazard = 3.96; P < .0001).
 DE    Adult  Alcohol, Ethyl/ADVERSE EFFECTS  AIDS-Related Opportunistic
       Infections/EPIDEMIOLOGY/*ETIOLOGY/  MORTALITY  CD4 Lymphocyte Count
       *Homosexuality, Male  Human  Male  Mycobacterium avium-intracellulare
       Infection/EPIDEMIOLOGY/  *ETIOLOGY/MORTALITY  Risk Factors  Support,
       U.S. Gov't, P.H.S.  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).