Document 0192
 DOCN  M95B0192
 TI    Observations on the pathological spectrum and clinical course of
       microsporidiosis in men infected with the human immunodeficiency virus:
       follow-up study.
 DT    9511
 AU    Rabeneck L; Genta RM; Gyorkey F; Clarridge JE; Gyorkey P; Foote LW; V.
       A. Medical Center (111D), Houston, Texas 77030, USA.
 SO    Clin Infect Dis. 1995 May;20(5):1229-35. Unique Identifier : AIDSLINE
       MED/95345290
 AB    The purposes of this research were to determine whether microsporidian
       infection is accompanied by structural alterations of the duodenal
       mucosa and to characterize the clinical and morphological evolution of
       intestinal microsporidiosis. In a previous systematic electron
       microscopic evaluation of mucosal biopsy specimens from patients with
       human immunodeficiency virus infection, we detected Enterocytozoon
       bieneusi in the duodenal tissue of 31 men. This report concerns a
       follow-up study of these 31 men, who underwent repeated clinical and
       laboratory evaluations, including repeated duodenal biopsies. Eighteen
       men had chronic diarrhea at enrollment and 13 had no diarrhea. The CD4+
       cell counts (per mm3) ranged from 10 to 660 and were normal for three
       men. E. bieneusi infection was accompanied by a wide spectrum of
       histopathology of duodenal tissue; over a mean follow-up of 15 months,
       no consistent change in duodenal mucosal morphology was observed, and
       diarrhea did not invariably develop. These observations indicate that
       diarrhea and severe villus injury do not invariably accompany infection.
       Further studies are needed to determine the relationship between E.
       bieneusi infection and clinical illness.
 DE    Adult  AIDS-Related Opportunistic Infections/*PATHOLOGY
       Duodenum/*PATHOLOGY/ULTRASTRUCTURE  Follow-Up Studies  Human  Intestinal
       Diseases, Parasitic/*PATHOLOGY  Intestinal Mucosa/PATHOLOGY  Male
       Microscopy, Electron  Microspora Infections/*PATHOLOGY  Support,
       Non-U.S. Gov't  Support, U.S. Gov't, Non-P.H.S.  Support, U.S. Gov't,
       P.H.S.  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).