Document 0194
 DOCN  M95B0194
 TI    Pulmonary disease due to infection by Mycobacterium avium complex in
       patients with AIDS.
 DT    9511
 AU    Kalayjian RC; Toossi Z; Tomashefski JF Jr; Carey JT; Ross JA; Tomford
       JW; Blinkhorn RJ Jr; Department of Medicine, Case Western Reserve
       University School of; Medicine, MetroHealth Medical Center, Cleveland,
       Ohio 44109-1998,; USA.
 SO    Clin Infect Dis. 1995 May;20(5):1186-94. Unique Identifier : AIDSLINE
       MED/95345285
 AB    We reviewed the clinical, radiographic, and histologic features of nine
       patients with AIDS and pulmonary disease due to Mycobacterium avium
       complex (MAC). Pulmonary MAC disease was defined by (1) the isolation of
       MAC from two or more lower respiratory tract specimens or from a single
       lung biopsy sample, (2) an infiltrate revealed by chest radiography, and
       (3) the absence of other identified pulmonary pathogens or malignancies.
       Pulmonary MAC disease was present in five (2.5%) of 200 patients with
       disseminated MAC infection and in four additional patients without
       evidence of dissemination, as assessed by blood culture. The median CD4
       cell count at the time of presentation was 90/microL. Pulmonary MAC
       disease was the initial AIDS-defining infection in five patients and
       presented within a median of 5 months after the initial infection in
       four patients. Radiographic patterns for these nine patients included
       consolidating or nodular infiltrates and cavitation. The histopathology
       of pulmonary MAC disease was characterized by granulomatous
       inflammation, often associated with necrosis and few evident organisms.
       The conditions of all patients treated with multidrug regimens
       clinically improved.
 DE    Adult  AIDS-Related Opportunistic Infections/DRUG THERAPY/*PATHOLOGY/
       RADIOGRAPHY  Case Report  Female  Human  Lung Diseases/DRUG
       THERAPY/*PATHOLOGY/RADIOGRAPHY  Male  Mycobacterium avium-intracellulare
       Infection/DRUG THERAPY/  *PATHOLOGY/RADIOGRAPHY  JOURNAL ARTICLE

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