Document 0226
 DOCN  M95B0226
 TI    Infections and immunological hazards of allogeneic bone transplantation.
 DT    9511
 AU    Hofmann GO; Kirschner MH; Wangemann T; Falk C; Mempel W; Hammer C;
       Chirurgische Klinik und Poliklinik,; Ludwig-Maximilians-Universitat,
       Klinikum Grosshadern, Munchen,; Germany.
 SO    Arch Orthop Trauma Surg. 1995;114(3):159-66. Unique Identifier :
       AIDSLINE MED/95344898
 AB    Allogeneic transplantation of human cancellous and cortical bone is a
       controversially discussed concept in trauma and orthopaedic surgery.
       Biological and immunological arguments support transplantation of
       autologous material whenever this is technically possible. On the other
       hand, synthetic alloplastic materials for bone substitution are
       available free of immunological and hygienic hazards. In this context
       the value of allogeneic bone grafts is discussed, especially considering
       the problem of AIDS. If autologous corticospongious bone is to be used
       its supply is limited. On the other hand, alloplastic synthetic
       artificial bone does not meet all the requirements demanded for
       substitution of large osseous defects up to now. The problems of
       geometric and mechanical stability of these alloplastic materials still
       remain. Therefore, no alternative to allografting of large, stable,
       corticospongious fragments exists in some cases. Bone transplantation is
       performed without vital indication in nearly every case. Thus an optimum
       of hygienic security has to be claimed for recipients of allogeneic
       bone. The Munich model for bone transplantation is presented and
       discussed.
 DE    Acquired Immunodeficiency Syndrome/TRANSMISSION  *Bone
       Transplantation/ADVERSE EFFECTS/CONTRAINDICATIONS/  IMMUNOLOGY/STANDARDS
       Communicable Diseases/TRANSMISSION  Graft Survival  Human  Risk
       Support, Non-U.S. Gov't  *Transplantation Immunology  Transplantation,
       Homologous  JOURNAL ARTICLE  REVIEW  REVIEW, TUTORIAL

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).