Document 0233
 DOCN  M95B0233
 TI    Immune status of newborns in perinatal chlamydial infection.
 DT    9511
 AU    Pirogova VI; Vinograd NA; Zhemela EM; Chegrinec NA; Department of
       Obstetrics, Gynecology, and Perinatology, Medical; Institute, Lviv,
       Ukraine.
 SO    Am J Reprod Immunol. 1995 Jan;33(1):94-6. Unique Identifier : AIDSLINE
       MED/95344472
 AB    PROBLEM: Thirty newborns, delivered by mothers with urogenital
       chlamydiosis, diagnosed on the 35th-36th weeks of gestation, and 10
       newborns of healthy mothers were studied immunologically. CD3
       (T-lymphocytes), CD19 (B-lymphocytes), CD4 (T-helpers-inductors), CD8
       (T-suppressor-cytotoxic), T-lymphocyte response to PHA, levels of Ig G,
       A, M in umbilical blood were detected. METHOD: Chlamydia trachomatis
       antibody's titers in umbilical blood were determined by indirect
       immunofluorescent method (with antigen C. trachomatis, serovar L2).
       Antibody titers found in umbilical blood were in 50% of cases higher
       than antibody level in mother's blood serum, and they later varied from
       1:64 to 1:256. It was established that newborns delivered by mothers
       with urogenital chlamydiosis had imbalance of T-lymphocyte subsets,
       decrease in the numbers of T- and B- lymphocytes, and increased level of
       Ig M, while the level of Ig G did not change significantly. The exposed
       disproportion in immune status neonatal, born from mothers with
       urogenital chlamydiosis, in combination with high C. trachomatis
       antibody titers in umbilical blood may be prognostic of the development
       of neonatal chlamydial infections.
 DE    Antibodies, Bacterial/IMMUNOLOGY  Antigens, CD/ANALYSIS  Antigens,
       CD3/ANALYSIS  Antigens, Differentiation, B-Lymphocyte/ANALYSIS
       Cervicitis  *Chlamydia trachomatis  Chlamydia
       Infections/*CONGENITAL/IMMUNOLOGY  CD4-CD8 Ratio  Female  Human  Infant,
       Newborn  Infant, Premature  Infant, Premature, Diseases/*IMMUNOLOGY
       *Lymphocyte Count  Lymphocyte Transformation  Pregnancy  *Pregnancy
       Complications, Infectious  *T-Lymphocyte Subsets/IMMUNOLOGY  JOURNAL
       ARTICLE

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