Document 0239
 DOCN  M95B0239
 TI    [Chronic herpes resistant to acyclovir in a patient with AIDS]
 DT    9511
 AU    About I; Capdeville J; Bernard P; Massip P; Service Medecine Interne,
       Hopital de Foix.
 SO    Ann Dermatol Venereol. 1994;121(11):810-3. Unique Identifier : AIDSLINE
       MED/95358532
 AB    INTRODUCTION. The prevalence of mucocutaneous herpetic infection is
       especially high in patients with the acquired immunodeficiency syndrome
       (AIDS). In these patients, 8 p. 100 of the chronic or recurrent herpetic
       lesions are due to a mutant strain. CASE REPORT. A case of very large
       (900 cm2) genital chronic herpetic infection is reported in a patient
       with AIDS (stade C3-CDC/WHO 1993). It was characterised by an acyclovir
       resistant strain which emerged after several anterior treatment with
       acyclovir. A treatment with foscarnet was administered and clinical
       improvement was observed as early as the fourth day, with complete
       reepithelialization 50 days later. DISCUSSION. We discussed essentially
       the pathogenicity of the herpetic infections due to mutant strains in
       immunocompromised patients and on the therapeutic modalities. At the
       present time, foscarnet is the treatment of choice for
       acyclovir-resistant mucocutaneous herpes simplex.
 DE    Acquired Immunodeficiency Syndrome/*COMPLICATIONS  Acyclovir/THERAPEUTIC
       USE  Adult  Buttocks  Case Report  Chronic Disease  Drug Resistance
       English Abstract  Foscarnet/THERAPEUTIC USE  Herpesviridae
       Infections/DRUG THERAPY/*ETIOLOGY  Human  Male  Skin Diseases,
       Viral/DRUG THERAPY/*ETIOLOGY  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).