Document 0242
 DOCN  M95B0242
 TI    Case report: vitamin D-mediated hypercalcemia in fungal infections.
 DT    9511
 AU    Spindel SJ; Hamill RJ; Georghiou PR; Lacke CE; Green LK; Mallette LE;
       Section of Infectious Disease, Veterans Affairs Medical Center,;
       Houston, TX 77030, USA.
 SO    Am J Med Sci. 1995 Aug;310(2):71-6. Unique Identifier : AIDSLINE
       MED/95358162
 AB    Hypercalcemia has been well described in a variety of neoplastic and
       granulomatous diseases. One mechanism for this hypercalcemia is via the
       excess production of 1,25-dihydroxyvitamin D from extra-renal sources.
       The authors describe an AIDS patient infected with Cryptococcus
       neoformans who had suggestive evidence of vitamin D-mediated
       hypercalcemia. He had an elevated serum 1,25-dihydroxyvitamin D value, a
       normal 25-hydroxyvitamin D value, and low values for parathyroid hormone
       and parathyroid hormone-related peptide. Most previously reported cases
       of hypercalcemia associated with fungal infections did not include
       sufficient evidence to implicate a role for excess 1,25-dihydroxyvitamin
       D production, except for two case reports involving patients with
       hypercalcemia with infections due to Pneumocystis carinii and Candida
       albicans. The authors' patient's hypercalcemia resolved during treatment
       of his underlying infection. Patients with hypercalcemia or in whom
       hypercalcemia develops during a disseminated fungal infection should
       have vitamin D metabolites measured as part of their work-up.
 DE    Acquired Immunodeficiency Syndrome/*COMPLICATIONS/METABOLISM  Adult
       AIDS-Related Opportunistic Infections/COMPLICATIONS/*METABOLISM
       Calcitriol/BLOOD  Case Report  Cryptococcosis/COMPLICATIONS/*METABOLISM
       Human  Hypercalcemia/BLOOD/*ETIOLOGY  Male  Support, U.S. Gov't,
       Non-P.H.S.  Support, U.S. Gov't, P.H.S.  Vitamin D/*METABOLISM  JOURNAL
       ARTICLE

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