Document 0291
 DOCN  M95B0291
 TI    Skin cancers associated with acquired immunodeficiency syndrome.
 DT    9511
 AU    Wang CY; Brodland DG; Su WP; Department of Dermatology, Mayo Clinic
       Rochester, Minnesota; 55905, USA.
 SO    Mayo Clin Proc. 1995 Aug;70(8):766-72. Unique Identifier : AIDSLINE
       MED/95356596
 AB    OBJECTIVE: To describe the types of skin cancer associated with the
       acquired immunodeficiency syndrome (AIDS). DESIGN: A literature review
       of AIDS-related mucocutaneous neoplasms, including basal cell carcinoma,
       squamous cell carcinoma, bowenoid papulosis and Bowen's disease,
       squamous cell carcinoma, cloacogenic carcinoma, and malignant melanoma,
       is presented, and the incidence, etiopathogenesis, clinicopathologic
       features, treatment, and prognosis are discussed. RESULTS: The
       association between cutaneous neoplasms and AIDS is well known.
       Neoplasms seem to grow more rapidly and be more invasive in patients
       with AIDS than in other groups of patients. Several oncogenic
       factors--for example, sunlight exposure or human papillomavirus
       infection--have been associated with the development of skin cancer in
       these patients. The morbidity and mortality rates of skin cancer are
       higher in patients infected with the human immunodeficiency virus (HIV)
       than in the general population. Early and complete excision of the
       neoplasm is especially important. CONCLUSION: A link exists between AIDS
       and the development of skin cancer. HIV-infected patients should be
       followed up vigilantly for early diagnosis of skin cancer. Because these
       patients are less able to suppress common cutaneous malignant disease
       due to their immunocompromised status, biopsy specimens should be
       obtained from all suspicious lesions, and histopathologic assessment
       should be done.
 DE    Acquired Immunodeficiency Syndrome/*COMPLICATIONS  Bowen's
       Disease/VIROLOGY  Carcinoma, Basal Cell/VIROLOGY  Carcinoma, Squamous
       Cell/VIROLOGY  Carcinoma, Transitional Cell/VIROLOGY  Human  Incidence
       Male  Melanoma/VIROLOGY  Prognosis  Skin
       Neoplasms/PATHOLOGY/THERAPY/*VIROLOGY  JOURNAL ARTICLE  REVIEW  REVIEW
       OF REPORTED CASES

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).