Document 0299
 DOCN  M95B0299
 TI    Tuberculosis and AIDS.
 DT    9511
 AU    Drobniewski FA; Pozniak AL; Uttley AH; Regional Tuberculosis Centre,
       Dulwich Public Health Laboratory,; King's College School of Medicine and
       Dentistry, London.
 SO    J Med Microbiol. 1995 Aug;43(2):85-91. Unique Identifier : AIDSLINE
       MED/95356214
 AB    Since the mid-1980s, the rate of decline in reported cases of
       tuberculosis (TB) has reached a plateau or reversed because of a
       combination of poverty and increased homelessness, immigration and
       displacement, poorly managed and supplied TB control programmes and,
       particularly in the developing world, the emergence of human
       immunodeficiency virus (HIV) infection. TB in HIV-positive patients may
       present atypically, both clinically and radiologically, with a lower
       probability of sputum positivity, greater difficulty in diagnosis, and a
       more rapid clinical deterioration than TB in HIV-seronegative patients.
       The emergence of multiple-drug-resistant strains of Mycobacterium
       tuberculosis, particularly in patients infected by HIV, carries a high
       mortality and has been associated with outbreaks in Europe and the USA.
       Microscopy and culture form the basis of diagnosis, but there is a need
       for more rapid diagnostic techniques and novel methods of drug
       susceptibility testing. Prolonged supervised treatment programmes and
       the development of new chemotherapeutic agents and regimens are
       essential prerequisites for successful TB therapy in AIDS patients. This
       review examines the clinical, microbiological and epidemiological issues
       associated with TB in HIV-infected individuals.
 DE    Acquired Immunodeficiency Syndrome/*COMPLICATIONS  *Developing Countries
       Europe/EPIDEMIOLOGY  Human  Incidence  Prevalence
       Tuberculosis/COMPLICATIONS/DRUG THERAPY/*EPIDEMIOLOGY  United
       States/EPIDEMIOLOGY  JOURNAL ARTICLE  REVIEW  REVIEW, TUTORIAL

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