Document 0008
 DOCN  M9650008
 TI    Resting energy expenditure and body composition in pediatric HIV
       infection.
 DT    9605
 AU    Alfaro MP; Siegel RM; Baker RC; Heubi JE; Department of Pediatrics,
       Children's Hospital Research; Foundation, Cincinnati, Ohio, USA.
 SO    Pediatr AIDS HIV Infect. 1995 Oct;6(5):276-80. Unique Identifier :
       AIDSLINE AIDS/96156176
 AB    One of the most striking features of HIV disease is the wasting syndrome
       or failure to thrive. Eighty percent of all perinatally HIV-infected
       children fail to grow normally. OBJECTIVE. Because severe malnutrition
       increases the morbidity of HIV infection and may shorten the already
       limited life expectancy of this population, we assessed resting energy
       needs, body composition, and nutrient intake in nine children
       perinatally HIV-infected, age 4 months to 4 years. DESIGN. Subjects were
       studied using measurements of resting energy expenditure (REE) by
       indirect calorimetry, body composition measurements by dual-energy X-ray
       absorptiometry (DEXA) and skinfolds, nutrient intake analysis by 24-hour
       recall, and serum protein levels. The HIV-infected children were free of
       secondary opportunistic infection at the time of the study. Subjects
       were reevaluated within the following year. RESULTS. REE correlated well
       (r = .856) with the predicted value from the World Health Organization
       (WHO) equation for basal energy expenditure. Measurement of percent body
       fat by skinfolds correlated well with DEXA percent body fat (r = .61).
       There was no significant difference between body fat assessed from
       skinfolds compared to published age-matched standards. All subjects met
       their recommended dietary allowance (RDA) for calories and protein. All
       subjects had adequate visceral protein stores for age. CONCLUSION.
       Perinatally infected children were not hypermetabolic when not
       secondarily infected and were able to maintain normal growth with the
       provision of adequate nutrition.
 DE    *Basal Metabolism  *Body Composition  *Caloric Intake  Calorimetry,
       Indirect  Child, Preschool  *Disease Transmission, Vertical  Failure to
       Thrive/*METABOLISM/VIROLOGY  Female  Human  HIV
       Infections/*COMPLICATIONS/TRANSMISSION  Infant  Longitudinal Studies
       Male  Nutrition Assessment  Nutritional Requirements  Support, U.S.
       Gov't, P.H.S.  JOURNAL ARTICLE

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