Document 0012
 DOCN  M9650012
 TI    [Substrate properties of dioxolane analogs of
       3'-deoxythymidine-5'-triphosphate in DNA synthesis reactions, catalyzed
       by various DNA polymerases]
 DT    9605
 AU    Efimtseva EV; Mikhailov SN; Viktorova LS; Rozovskaia TA; Bibilashvili
       RSh
 SO    Bioorg Khim. 1995 Oct;21(10):781-9. Unique Identifier : AIDSLINE
       MED/96096923
 AB    The substrate properties of 3'-deoxythymidine 5'-triphosphate analogs
       prepared on the basis of 2,4-disubstituted 1,3-dioxolanes were
       investigated in reactions of the DNA synthesis catalyzed by various DNA
       polymerases. The 4'-triphosphates of
       (+/-)-cis-4-hydroxymethyl-2-(1-thyminylmethyl)-1,3-dioxolane and the
       corresponding (+/-)-trans-isomer were shown to be terminating substrates
       of terminal deoxynucleotidyl transferase. 4'-Triphosphate of
       (+/-)-cis-4-hydroxymethyl-2-(1-thyminylmethyl)- 1,3-dioxolane terminates
       the DNA synthesis catalyzed by HIV reverse transcriptase, whereas
       2'-triphosphate of
       (+/-)-cis-2-hydromethyl-4-(1-thyminylmethyl)-1,3-dioxolane is a
       terminator in the DNA synthesis catalyzed by HIV reverse transcriptase
       and the Klenow fragment of DNA polymerase I.
 DE    Base Sequence  Catalysis  Dioxolanes/*CHEMISTRY  DNA Polymerase
       I/*METABOLISM  English Abstract  HIV/ENZYMOLOGY  Molecular Sequence Data
       Nuclear Magnetic Resonance  RNA-Directed DNA Polymerase/METABOLISM
       Substrate Specificity  Thymine Nucleotides/CHEMISTRY/*METABOLISM
       JOURNAL ARTICLE

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