Document 0013
 DOCN  M9650013
 TI    [Identification of immunoreactive epitopes in proteins coded by gag,
       env, and pol genes of the type I human T-lymphotropic virus (HTLV-I)
       using synthetic peptides]
 DT    9605
 AU    Iaroslavtseva NG; Ivanov VS; Grebennikova ZhO; Kornilaeva GV; Pashkova
       TA; Chikin LD; Ostrovskii AG; Andreev SM; Khaitov RM; Karamov EV
 SO    Bioorg Khim. 1995 Oct;21(10):752-60. Unique Identifier : AIDSLINE
       MED/96096919
 AB    Reactivity of 26 synthetic peptides that comprise 12 to 26 amino acid
       residues corresponding to segments of the gag p19, env gp46, and pol
       proteins of human T-lymphotropic virus type I toward 31 positive sera
       was studied using enzyme-linked immunosorbent assay. Specific reactivity
       with high titers of antibodies (presented in reciprocal dilution values)
       was detected for the synthetic peptides corresponding to fragments
       110-130 and 100-130 (titers up to 4050) of p19, 174-197 (up to 800),
       186-201 (up to 4050), 191-215 (up to 1350), 242-257 (up to 800), and
       272-292 (up to 450) of gp46. Immunoreactivity of seven peptides,
       fragments of pol-proteins, was weak. New linear epitopes in the regions
       145-158, 272-277, and 292-300 of gp46 were detected. In addition,
       location of the known linear epitopes in p19 and gp46 was refined on the
       basis of comparative study of overlapping peptides from these proteins.
 DE    Amino Acid Sequence  English Abstract  Enzyme-Linked Immunosorbent Assay
       Epitopes/*ANALYSIS/IMMUNOLOGY  Gene Products, env/*IMMUNOLOGY  Gene
       Products, gag/*IMMUNOLOGY  Gene Products, pol/*IMMUNOLOGY  Human
       HTLV-I/*GENETICS  HTLV-I Infections/BLOOD  Molecular Sequence Data
       Peptides/*CHEMISTRY  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).