Document 0019
 DOCN  M9650019
 TI    Both SU and TM env proteins are responsible for monkey cell tropism of
       simian immunodeficiency virus SIV mac.
 DT    9605
 AU    Sakuragi S; Sakuragi J; Adachi A; Institute for Virus Research, Kyoto
       University, Japan.
 SO    Arch Virol. 1995;140(12):2255-60. Unique Identifier : AIDSLINE
       MED/96140618
 AB    While simian immunodeficiency virus (SIV) derived from an infectious
       molecular clone pMA239 is tropic and pathogenic for monkeys, the virus
       derived from another infectious clone pMA142 does not replicate in
       monkey cells. To determine genetic sequences responsible for this
       tropism, a series of recombinant clones were constructed from pMA142 and
       pMA239. The determinant in pMA239 was mapped within regions encompassing
       the env gene. Viruses, which carry the 239 env gene encoding surface
       and/or transmembrane proteins, were tropic for monkey cells.
 DE    Animal  Cell Line  Comparative Study  Gene Products,
       env/BIOSYNTHESIS/*GENETICS  Genes, env  Human  Kinetics  Macaca
       Recombination, Genetic  Restriction Mapping  Species Specificity
       Support, Non-U.S. Gov't  SIV/*GROWTH & DEVELOPMENT/GENETICS/PHYSIOLOGY
       Time Factors  Virus Replication  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).