Document 0020
 DOCN  M9650020
 TI    Host dependent variation of hepatitis C virus: phylogenetic analyses.
 DT    9605
 AU    Maekawa S; Enomoto N; Kurosaki M; Marumo F; Sato C; Second Department of
       Internal Medicine, Tokyo Medical and Dental; University, Japan.
 SO    Arch Virol. 1995;140(12):2123-33. Unique Identifier : AIDSLINE
       MED/96140609
 AB    Hepatitis C virus quasispecies in six patients from three families were
       separated by single strand conformation polymorphism analysis and by
       determination of nucleotide sequences of envelope regions containing the
       E1 gene segment and hypervariable region-1 of each quasispecies. Four of
       the six patients had multiple quasispecies. Phylogenetic analyses
       indicated that all quasispecies from one individual were highly
       homologous to each other. The homology was higher in the E1 gene segment
       than in hypervariable region-1. Furthermore, all quasispecies found in
       members of one family (husband and wife) were also highly homologous,
       suggesting direct intrafamilial transmission. The direction of hepatitis
       C virus variation in hypervariable region-1, however, seems to differ
       depending on the host in intrafamilial transmission.
 DE    Adolescence  Aged  Base Sequence  Case Report  Comparative Study  DNA
       Primers  Female  Genes, env  Hepatitis C/BLOOD  Hepatitis C
       Viruses/*CLASSIFICATION/*GENETICS/ISOLATION & PURIF  Human  Male  Middle
       Age  Molecular Sequence Data  *Phylogeny  Polymerase Chain Reaction
       Polymorphism, Single-Stranded Conformational  RNA,
       Viral/ANALYSIS/GENETICS  Support, Non-U.S. Gov't  *Variation (Genetics)
       JOURNAL ARTICLE

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