Document 0022
 DOCN  M9650022
 TI    Interferon and tumor necrosis factor responses of HIV+ patients as
       markers for monitoring of the AIDS progression.
 DT    9605
 AU    Piasecki E; Ledwon TK; Inglot AD; Knysz B; Simon K; Inglot M; Gladysz A;
       Laboratory of Virology, Polish Academy of Sciences, Wroclaw.
 SO    Arch Immunol Ther Exp (Warsz). 1994;42(5-6):439-45. Unique Identifier :
       AIDSLINE MED/96171330
 AB    The blood samples taken from 31 HIV+ and AIDS patients were used to
       study interferon (IFN) and tumor necrosis factor (TNF) responses. The
       IFN and TNF levels in plasma were determined. In the whole blood assay
       (whole blood diluted 1:10 with culture medium) Newcastle disease virus
       (NDV) and phytohemagglutinin (PHA) were used as cytokine inducers. Blood
       leukocytes of HIV+ patients produced significantly less IFN-alpha after
       NDV stimulation than the cells of healthy (HIV-) individuals. On the
       other hand, the production of IFN-gamma in response to PHA was impaired
       only in AIDS patients with stage CDC IV and CD4+ cell number <
       200/microliters. These patients had also increased IFN levels in plasma.
       Particularly, the high level of IFN in plasma was frequently detected in
       patients with progressing AIDS with CD4+ cell number < 50/microliters.
       This type of IFN was identified as a mixture of acid-labile and
       acid-stable IFN-alpha. The IFN responses of HIV+ patients may be
       considered as markers for monitoring progression of AIDS and therapy.
 DE    Acquired Immunodeficiency Syndrome/*BLOOD/IMMUNOLOGY  Adolescence  Adult
       Biological Markers/BLOOD  Comparative Study  CD4 Lymphocyte Count
       Disease Progression  Female  Human  HIV Infections/*BLOOD/IMMUNOLOGY
       Interferon Inducers/PHARMACOLOGY  Interferons/BIOSYNTHESIS/*BLOOD
       Leukocytes/DRUG EFFECTS/METABOLISM/VIROLOGY  Male  Middle Age  Newcastle
       Disease Virus  Phytohemagglutinins/PHARMACOLOGY  Reference Values
       Support, Non-U.S. Gov't  Tumor Necrosis Factor/BIOSYNTHESIS/*METABOLISM
       JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
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