Document 0026
 DOCN  M9650026
 TI    [Lymphoma with skin manifestations in HIV infection: 8 cases]
 DT    9605
 AU    Esteve E; Bagot M; Grange F; Beylot-Barry M; D'Incan M; Vaillant L;
       Laroche L; Joly P; Pradinaud R; Vergier B; et al; Service de
       Dermatologie, Hopital Robert-Debre, Reims.
 SO    Ann Dermatol Venereol. 1995;122(8):488-93. Unique Identifier : AIDSLINE
       MED/96146750
 AB    INTRODUCTION. Cutaneous lymphomas occurring in HIV infection are a rare
       disease. Most of them are high grade lymphomas with fulminant course and
       poor prognosis. OBJECTIVE. Evaluate clinical and histological aspects as
       well as immunophenotype and evolution of these lymphomas. PATIENTS AND
       METHODS. Eight patients with HIV infection were studied between 1992 and
       1994. The clinical and histological features were reviewed by the
       members of the French Study Group for Cutaneous Lymphomas. Staging
       procedures for lymphomas were performed in 7/8 patients. RESULTS. Seven
       non epidermotropic lymphomas and one mycosis fungoides were reviewed.
       Patients were male (6 cases) and female (2 cases); their mean age was 45
       years (27-63). The mean level of CD4 T cells/mm3 was 141 (20-380). Only
       one patient presented with extracutaneous lesions. These lesions were
       similar to seronegative patients, but unusual features were observed in
       two cases. Histological classification showed high grade lymphomas in
       6/8 cases. The immunophenotype was: T-cell lymphoma in 4 cases, B-cell
       lymphoma in 3 cases; it could not be determinated in one case. Six
       patients died. The median of survival is 8 months in this series.
       DISCUSSION. Our series confirms the predominance of high grade lymphomas
       presenting in the skin. The T-cell phenotype is more frequent. The onset
       of a cutaneous lymphoma has a poor prognosis in HIV infection. Most of
       our patients had localised disease at presentation. Therapeutic
       management of these lymphomas must be codified.
 DE    Adult  English Abstract  Female  Human  *Lymphoma,
       AIDS-Related/PATHOLOGY/PHYSIOPATHOLOGY/THERAPY  Male  Middle Age
       Phenotype  *Skin Neoplasms/PATHOLOGY/PHYSIOPATHOLOGY/THERAPY  Time
       Factors  JOURNAL ARTICLE  REVIEW  REVIEW OF REPORTED CASES

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).