Document 0029
 DOCN  M9650029
 TI    Ultrastructural findings in the vestibular end-organs of AIDS cases.
 DT    9605
 AU    Pappas DG Jr; Roland JT Jr; Lim J; Lai A; Hillman DE; Department of
       Otolaryngology, NYU Medical Center, NY 10016, USA.
 SO    Am J Otol. 1995 Mar;16(2):140-5. Unique Identifier : AIDSLINE
       MED/96149069
 AB    Neurotologic manifestations are apparent in human immunodeficiency virus
       (HIV) infection, but are poorly understood. Symptoms related to the
       vestibular system include episodes of vertigo, imbalance, ataxia, and
       nausea. Although patients present more often with hearing impairment,
       vestibular complaints are described and electrophysiologic studies
       indicate vestibular dysfunction in HIV-infected patients. Whether the
       disease involvement includes the central, or the peripheral nervous
       system has not been established. Ultrastructural analysis of vestibular
       end-organs obtained from HIV autopsy cases revealed pathologic changes
       in the labyrinth wall, the epithelial lining, and the receptor maculae
       and cristae. Cytologic changes in hair cells included inclusion bodies,
       viral-like particles, and hair bundle malformations. Epithelial lining
       cells, supporting cells, and connective tissue cells had inclusions and
       viral-like particles. These findings are consistent with those of a
       previous cochlear study demonstrating intracellular viral-like particles
       with the morphologic characteristics of HIV. Further cytologic
       evaluation of decalcified temporal bones and immunohistochemical
       analysis of freshly harvested HIV-infected temporal bones may provide
       further insight into the pathogenesis of viral-induced hearing loss and
       vestibular impairment.
 DE    Acquired Immunodeficiency Syndrome/*PATHOLOGY  Adult  Connective
       Tissue/ULTRASTRUCTURE/VIROLOGY  Hair Cells, Vestibular/*ULTRASTRUCTURE
       Human  Inclusion Bodies, Viral/ULTRASTRUCTURE  Middle Age  Temporal
       Bone/ULTRASTRUCTURE  Vestibular Diseases/*PATHOLOGY/VIROLOGY
       Vestibule/*ULTRASTRUCTURE/VIROLOGY  JOURNAL ARTICLE

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