Document 0031
 DOCN  M9650031
 TI    Simian immunodeficiency virus variants: threat of new lentiviruses.
 DT    9605
 AU    McClure HM; Novembre FJ; Yerkes Regional Primate Research Center, Emory
       University,; Atlanta, Georgia 30322, USA.
 SO    Am J Med Sci. 1996 Jan;311(1):30-3. Unique Identifier : AIDSLINE
       MED/96164689
 AB    Infection in humans with the lentivirus HIV-1 typically results in the
       development of a chronic disease state characterized by the slow decline
       of CD4+ lymphocytes, the development of immunosuppression, and the
       development of opportunistic infections, ultimately leading to death.
       Although the average course of disease runs approximately 10 years,
       shorter and longer progression times have been noted. These alterations
       are presumed to be, at least partially, a factor of viral variation. The
       simian immunodeficiency viruses (SIVs) are the nonhuman primate
       counterparts to HIV. Several of these isolates, including SIV from sooty
       mangabey monkeys, induce a remarkably similar disease in Asian macaques.
       Recently, variants of SIV from sooty mangabey monkeys and SIV from
       African green monkeys have been described, which are increasingly more
       pathogenic. As in HIV-1 infections, this is probably due to genetic
       variation. On the basis of these findings, atypical viruses with
       tremendous pathogenic potential can arise from apathogenic or moderately
       pathogenic viruses.
 DE    Acquired Immunodeficiency Syndrome/VIROLOGY  Animal  Cercocebus atys
       Cercopithecus aethiops  Comparative Study  Human  HIV-1  Lentivirus
       Infections/*VETERINARY  Macaca  *Primate Diseases  Primates  Simian
       Acquired Immunodeficiency Syndrome/*PHYSIOPATHOLOGY  Support, U.S.
       Gov't, P.H.S.  SIV/*GENETICS/ISOLATION & PURIF/PATHOGENICITY  Variation
       (Genetics)  JOURNAL ARTICLE  REVIEW  REVIEW, TUTORIAL

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).