Document 0058
 DOCN  M9650058
 TI    [Effect of primary prevention of Pneumocystis carinii pneumonia on the
       inaugural clinical and biological presentation of AIDS: 624 cases
       (Aquitaine Cohort, 1985-1994)]
 DT    9605
 AU    Morlat P; Hubert JB; Chene G; Buisson M; Paty MC; Lasseur C; Constans J;
       Bernard N; Beylot J; Service de medecine interne, hopital Saint-Andre,
       Bordeaux,; France.
 SO    Rev Med Interne. 1995;16(11):815-7. Unique Identifier : AIDSLINE
       MED/96145680
 AB    In a cohort of HIV-infected patients, this study compares the clinical
       and immunological features at the time of AIDS diagnosis of patients who
       either received primary Pneumocystis carinii prophylaxis (P+; n = 335)
       or who did not (P-; n = 289). Frequency of P carinii pneumonia was lower
       in P+ than in P- patients (14.9% vs 26.0%; p < 0.001). Conversely,
       toxoplasmic encephalitis, esophageal candidiasis, cytomegalovirus
       disease and M avium complex disease were more frequent in P+ patients.
       CD4+ count (median/mm3) at the time of AIDS diagnosis was lower in P+
       than in P- patients: 22 vs 97 (p < 0.001); this suggests that early
       intervention delays the onset of AIDS for about one year. While
       searching for new prevention strategies against other opportunistic
       infections, efforts should be expanded to improve prophylaxis of P
       carinii pneumonia which remains in France the most frequent first
       AIDS-related illness.
 DE    Acquired Immunodeficiency Syndrome/*EPIDEMIOLOGY  AIDS-Related
       Opportunistic Infections/EPIDEMIOLOGY/*PREVENTION &  CONTROL  Cohort
       Studies  English Abstract  Female  France/EPIDEMIOLOGY  Hospitals,
       University  Human  HIV Infections/DRUG
       THERAPY/*EPIDEMIOLOGY/PHYSIOPATHOLOGY  HIV-1  Male  Pneumonia,
       Pneumocystis carinii/EPIDEMIOLOGY/*PREVENTION &  CONTROL  Support,
       Non-U.S. Gov't  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).