Document 0063
 DOCN  M9650063
 TI    Synthesis and biological activity of 1,2,4-triazinotriazinone
       derivatives.
 DT    9605
 AU    Abdel-Halim AM; el-Gendy Z; Abdel-Rahman RM; Department of Chemistry,
       Faculty of Education,; Ain-Shams-University, Roxy, Cairo, Egypt.
 SO    Pharmazie. 1995 Nov;50(11):726-9. Unique Identifier : AIDSLINE
       MED/96128321
 AB    The synthesis of 1,2,4-triazines bearing a 1,2,4-triazinone moiety and
       of 1,2,4-triazolo[4,3-b]-1,2,4-triazonones have been achieved by
       reaction of 1,6-dihydro-3-hydrazino-6-spiro-
       (9-fluorenyl)-1,2,4-triazin-5(4H)-one with various oxo- and
       halo-compounds. Structures of the products have been deduced by
       elemental analysis and spectral data. Significant anti-HIV and
       anticancer activities were observed in vitro for some members of the
       series.
 DE    Antineoplastic Agents/*CHEMICAL SYNTHESIS/*PHARMACOLOGY  Antiviral
       Agents/*CHEMICAL SYNTHESIS/*PHARMACOLOGY  Drug Screening Assays,
       Antitumor  Human  HIV/*DRUG EFFECTS  Microbial Sensitivity Tests
       Triazines/*CHEMICAL SYNTHESIS/*PHARMACOLOGY  Tumor Cells, Cultured
       JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).