Document 0073
 DOCN  M9650073
 TI    Cytomegalovirus optic neuritis: characteristics, therapy and survival.
 DT    9605
 AU    Mansor AM; Li HK; Department of Ophthamology, University of Texas
       Medical Branch,; Galveston 77555-0787, USA.
 SO    Ophthalmologica. 1995;209(5):260-6. Unique Identifier : AIDSLINE
       MED/96141238
 AB    Little is known about the natural history of cytomegalovirus (CMV) optic
       neuritis in the acquired immunodeficiency syndrome. We analyzed the
       clinical course of CMV optic neuritis in 30 consecutive subjects (35
       eyes), and compared the survival of patients with CMV optic neuritis to
       that of a group having CMV retinitis alone, with both groups matched for
       ganciclovir therapy. Four untreated eyes had a median final visual
       acuity of no light perception. The median final visual acuity was 20/100
       in treated subjects with a mean follow-up of 6.6 months. Following
       ganciclovir treatment, 2 eyes showed visual improvement, 17 eyes had
       unchanged visual acuity, and 12 eyes had marked drop in acuity. Relapse
       occurred in 4 subjects maintained on single-dose ganciclovir, and was
       controlled on double-dose ganciclovir. Survival was similar in the group
       of CMV retinitis alone versus the group of CMV optic neuritis with
       retinitis. Early recognition and therapy of CMV optic neuritis protects
       against irreversible visual loss. CMV optic neuritis does not carry a
       worse prognosis for survival than CMV retinitis alone.
 DE    Adult  Antiviral Agents/ADMINISTRATION & DOSAGE/*THERAPEUTIC USE
       AIDS-Related Opportunistic Infections/DRUG THERAPY/*ETIOLOGY/  MORTALITY
       Comparative Study  Cytomegalovirus Infections/DRUG
       THERAPY/*ETIOLOGY/MORTALITY  Cytomegalovirus Retinitis/DRUG
       THERAPY/ETIOLOGY/MORTALITY  Eye Infections, Viral/DRUG
       THERAPY/*ETIOLOGY/MORTALITY  Female  Follow-Up Studies  Fundus Oculi
       Ganciclovir/ADMINISTRATION & DOSAGE/*THERAPEUTIC USE  Human  Male
       Middle Age  Optic Nerve/PATHOLOGY  Optic Neuritis/DRUG
       THERAPY/MORTALITY/*VIROLOGY  Prospective Studies  Recurrence
       Retinitis/PATHOLOGY  Retrospective Studies  Survival Rate  Visual Acuity
       Visual Fields  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).