Document 0074
 DOCN  M9650074
 TI    Immunoscintigraphy with a 99Tcm-labelled anti-granulocyte monoclonal
       antibody in patients with human immunodeficiency virus infection and
       AIDS.
 DT    9605
 AU    Prvulovich EM; Miller RF; Costa DC; Severn A; Corbett E; Bomanji J;
       Becker WS; Ell PJ; Institute of Nuclear Medicine, University College
       London Medical; School, UK.
 SO    Nucl Med Commun. 1995 Oct;16(10):838-45. Unique Identifier : AIDSLINE
       MED/96123947
 AB    The value of immunoscintigraphy with technetium-99m (99Tcm) labelled
       anti-granulocyte monoclonal antibody (BW250/183) was studied
       prospectively in human immunodeficiency virus (HIV-1) antibody-positive
       patients presenting with fever without localizing symptoms or signs.
       Twenty-three studies were performed in 23 patients and the results of
       99Tcm-anti-granulocyte imaging were compared with the definitive
       microbiological or cytological diagnosis. Twenty-one patients had an
       infective cause of pyrexia, one patient had disseminated lymphoma and
       one Kaposi sarcoma. 99Tcm-anti-granulocyte antibody imaging correctly
       identified the sites of infection in only five (24%) patients, four of
       whom had infective colitis (one also had bacterial pneumonia) and one of
       whom had cellulitis. Sixteen foci of infection were not localized by
       99Tcm-anti-granulocyte immunoscintigraphy (false-negative scans). Six of
       these patients had Pneumocystis carinii pneumonia; other diagnoses in
       this group included bacterial or fungal pneumonia and bacteraemia
       secondary to line infections. 99Tcm-anti-granulocyte antibody did not
       accumulate in the patients with disseminated lymphoma and Kaposi sarcoma
       (true-negative scans). 99Tcm-anti-granulocyte imaging, therefore,
       appears useful in identifying extrathoracic infection in HIV-1 positive
       patients. Its lack of sensitivity for the identification of pulmonary
       infection means that its role in the investigation of HIV-1
       antibody-positive patients with fever without localizing symptoms or
       signs is limited.
 DE    Adult  Antibodies, Monoclonal/*DIAGNOSTIC USE/IMMUNOLOGY  Antibody
       Specificity  AIDS-Related Opportunistic Infections/*RADIONUCLIDE IMAGING
       Bacterial Infections/RADIONUCLIDE IMAGING  False Negative Reactions
       False Positive Reactions  Fever of Unknown Origin/*RADIONUCLIDE IMAGING
       Granulocytes/*IMMUNOLOGY  Human  HIV Infections/*COMPLICATIONS
       Immunoconjugates/*DIAGNOSTIC USE  Lung Neoplasms/ETIOLOGY/RADIONUCLIDE
       IMAGING  Lymphoma, AIDS-Related/RADIONUCLIDE IMAGING  Male  Middle Age
       Mycoses/RADIONUCLIDE IMAGING  Pneumonia/ETIOLOGY/*RADIONUCLIDE IMAGING
       Pneumonia, Pneumocystis carinii/RADIONUCLIDE IMAGING  Prospective
       Studies  *Radioimmunodetection  Sarcoma, Kaposi's/ETIOLOGY/RADIONUCLIDE
       IMAGING  Sodium Pertechnetate Tc 99m/*DIAGNOSTIC USE  Virus
       Diseases/RADIONUCLIDE IMAGING  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).