Document 0087
 DOCN  M9650087
 TI    Con A cytotoxicity: a model for the study of key signaling steps leading
       to lymphocyte apoptosis in AIDS?
 DT    9605
 AU    Pitts OM
 SO    Med Hypotheses. 1995 Sep;45(3):311-5. Unique Identifier : AIDSLINE
       MED/96130676
 AB    Lymphocytes respond to mitogens, viruses and other activation agents
       with hydrogen peroxide or reactive oxygen bursts which may originate at
       or near the cell membrane. It has been shown that a very small increase
       in the ratio of Con A cells results in a rapid switchover from
       mitogenicity to cytotoxicity. It is hypothesized that the change from
       mitogenicity to cytotoxicity correlates with the strength and duration
       of the hydrogen peroxide or reactive oxygen bursts which in turn depends
       on the number of molecules of the activation agent bound per cell. This
       hypothesis is presented and discussed in the context of the apoptosis
       (programmed cell death) and pro-oxidant-antioxidant hypothesis of CD4+
       T-cell and B-cell subpopulation depletion in AIDS.
 DE    Acquired Immunodeficiency Syndrome/*PATHOLOGY  Antioxidants/METABOLISM
       Apoptosis/DRUG EFFECTS/*PHYSIOLOGY  B-Lymphocyte Subsets/DRUG
       EFFECTS/IMMUNOLOGY/METABOLISM  Concanavalin A/*TOXICITY  CD4-Positive
       T-Lymphocytes/DRUG EFFECTS/IMMUNOLOGY/METABOLISM  Human  Hydrogen
       Peroxide/*METABOLISM  HIV Envelope Protein gp120/PHARMACOLOGY  Leukemia,
       T-Cell/PATHOLOGY  Lymphocytes/*DRUG
       EFFECTS/IMMUNOLOGY/METABOLISM/PATHOLOGY  Measles Virus/PHYSIOLOGY
       Mitosis  Models, Biological  Oxidants/METABOLISM  Oxidative Stress
       Reactive Oxygen Species/*METABOLISM  Signal Transduction/*DRUG EFFECTS
       Tumor Cells, Cultured  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).