Document 0088
 DOCN  M9650088
 TI    From pseudocholinesterase to human immunodeficiency virus.
 DT    9605
 AU    Madhavankutty K; Shyamasundar K; Andrews W; Department of Pediatrics,
       Faculty of Medicine, Memorial; University of Newfoundland, Canada.
 SO    Med Hypotheses. 1995 Sep;45(3):225-6. Unique Identifier : AIDSLINE
       MED/96130661
 AB    Pseudocholinesterase is a protein for which no function exists in
       mammals including human beings. To date, no substrate has been
       identified for this 'enzyme'. Involvement of this protein in the
       aetiopathogenesis of many diseases, such as hyperlipoproteinaemia, is
       still actively debated. Here, we propose a theoretical method to
       immobilize pseudocholinesterase in hepatocytes using antibody bound to
       liposomes. Conceptually, this approach will have widespread application,
       especially in blocking human immunodeficiency virus replication in vivo.
 DE    Animal  Antibodies/*ADMINISTRATION & DOSAGE  Apolipoproteins
       E/*ADMINISTRATION & DOSAGE/METABOLISM  Biochemistry/*METHODS
       Chloroquine/PHARMACOLOGY  Drug Carriers  Endocytosis  Enzyme Activation
       Human  HIV/*ENZYMOLOGY  HIV Antibodies/*ADMINISTRATION & DOSAGE  HIV
       Envelope Protein gp120/*ADMINISTRATION & DOSAGE/METABOLISM  HIV
       Infections/DRUG THERAPY/THERAPY/VIROLOGY
       Immunoconjugates/*ADMINISTRATION & DOSAGE  Immunotherapy/*METHODS
       Liposomes  Liver/*ENZYMOLOGY  Lysosomes/DRUG EFFECTS/ENZYMOLOGY
       Mammals/METABOLISM  Pseudocholinesterase/IMMUNOLOGY/*PHYSIOLOGY
       Receptors, Lipoprotein/METABOLISM  *RNA-Directed DNA
       Polymerase/IMMUNOLOGY  Zidovudine/ADMINISTRATION & DOSAGE  JOURNAL
       ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).