Document 0092
 DOCN  M9650092
 TI    Low occurrence of arthritic manifestations in patients with pulmonary
       tuberculosis. T cell subsets and humoral studies.
 DT    9605
 AU    Dlugovitzky D; Torres A; Hourquescos MC; Svetaz MJ; Quagliato N;
       Valentini E; Amigot B; Molteni O; Bottasso O; Catedra de Microbiologia,
       Facultad de Ciencias Medicas,; Universidad Nacional de Rosario,
       Argentina.
 SO    Mem Inst Oswaldo Cruz. 1995 Sep-Oct;90(5):623-8. Unique Identifier :
       AIDSLINE MED/96092394
 AB    Given the suspected role of mycobacteria in the establishment of
       disorders with an autoimmune background and joint damage, a study was
       conducted to analyze whether rheumatic symptoms were likely to be
       present in tuberculosis (TB) patients. To this end, 330 patients with a
       bacteriologic confirmation of tuberculosis were investigated for the
       presence of arthritic complaints. The latter were recorded in five of
       them with rheumatic symptoms mostly involving interphalangeal and
       metacarpophalangeal joints, and preceding the clinical manifestations of
       the TB illness. Three out of these five patients remained arthritic by
       the time of the bacteriologic conversion and fulfilled the criteria for
       the diagnosis of rheumatoid arthritis. In the two remaining patients
       sputum negativization was accompanied by a disappearance of rheumatic
       manifestations. These patients were also assessed for their peripheral
       levels of major T cell subsets as well as for the presence of
       autoantibodies. Comparisons with a series of non-arthritic TB cases,
       rheumatoid arthritis patients, and controls revealed that presence of
       rheumatic manifestations was associated with a different profile of
       autoantibody formation and T cell subset changes. Evidence recorded in
       the present study indicates that joint affectation in TB is a rare
       event, being rather the exception than the rule.
 DE    Adult  Antibody Formation  Arthritis, Rheumatoid/*IMMUNOLOGY
       Autoantibodies/ANALYSIS  CD4-CD8 Ratio  Female  Human  Male  Middle Age
       Support, Non-U.S. Gov't  T-Lymphocyte Subsets  Tuberculosis,
       Pulmonary/*COMPLICATIONS/IMMUNOLOGY  JOURNAL ARTICLE

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