Document 0109
 DOCN  M9650109
 TI    Distribution of CD1a-positive Langerhans cells and lymphocyte subsets in
       transitional cell carcinoma of the urinary bladder. An
       immunohistological study on frozen sections.
 DT    9605
 AU    Ioachim-Velogianni E; Stavropoulos NE; Kitsiou E; Stefanaki S; Agnantis
       NJ; Department of Pathology, University of Ioannina Medical School,;
       Greece.
 SO    J Pathol. 1995 Dec;177(4):401-6. Unique Identifier : AIDSLINE
       MED/96165097
 AB    The distribution of CD1a-positive Langerhans cells, CD4-positive
       T-helper cells, and CD8-positive T-suppressor cells in 36 patients with
       transitional cell carcinoma of the urinary bladder was studied
       immunohistochemically on frozen sections. Multiple tissue specimens from
       the tumour, the adjacent mucosa, and random bladder wall biopsies were
       examined. Langerhans cells were mainly interspersed among the tumour
       cells, whereas T-helper cells were present in aggregates in the stroma.
       T-suppressor cells were present both in aggregates in the stroma and
       among the tumour cells. There was a marginal relationship between the
       density of Langerhans cells and the density of T-helper/inducer cells
       and a good relationship with CD8-positive cells. There was no
       statistically significant difference in the population density of
       Langerhans cells associated with the various clinicopathological
       variables, including growth pattern, histological grade and stage, or
       patient's age and sex. On the contrary, a statistically significant
       difference was found in the CD1a/CD4 ratio among specimens of different
       grades. These results show that CD1a cell populations correlate with
       T-cell populations in bladder cancer, suggesting that Langerhans cells
       take part in the immune response carried out by T lymphocytes, their
       task being apparently antigen presentation.
 DE    Adult  Aged  Aged, 80 and over  Antigens, CD1/*ANALYSIS  Bladder
       Neoplasms/*IMMUNOLOGY  Carcinoma, Transitional Cell/*IMMUNOLOGY
       Cryopreservation  CD4-Positive T-Lymphocytes/IMMUNOLOGY  CD8-Positive
       T-Lymphocytes/IMMUNOLOGY  Female  Human  Immunoenzyme Techniques
       Langerhans Cells/*IMMUNOLOGY  Male  Middle Age  T-Lymphocyte
       Subsets/*IMMUNOLOGY  JOURNAL ARTICLE

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